Acute kidney injury following liver transplantation: Definition and outcome

Yousri M. Barri, Edmund Q. Sanchez, Linda W. Jennings, Larry B. Melton, Steven Hays, Marlon F. Levy, Goran B. Klintmalm – 27 April 2009 – The incidence of acute kidney injury (AKI) has been reported to vary between 17% and 95% post–orthotopic liver transplantation. This variability may be related to the absence of a uniform definition of AKI in this setting. The purpose of this study was to identify the degree of AKI that is associated with long‐term adverse outcome.

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M. Isabel Lucena, Carmen Martínez, Raúl J. Andrade, Elena García‐Martín, Eugenia Ulzurrun, José A. G. Agúndez – 27 April 2009

MicroRNA‐122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma

Wei‐Chih Tsai, Paul Wei‐Che Hsu, Tsung‐Ching Lai, Gar‐Yang Chau, Ching‐Wen Lin, Chun‐Ming Chen, Chien‐Der Lin, Yu‐Lun Liao, Jui‐Ling Wang, Yat‐Pang Chau, Ming‐Ta Hsu, Michael Hsiao, Hsien‐Da Huang, Ann‐Ping Tsou – 27 April 2009 – MicroRNAs (miRNAs), which are inhibitors of gene expression, participate in diverse biological functions and in carcinogenesis. In this study, we show that liver‐specific microRNA‐122 (miR‐122) is significantly down‐regulated in liver cancers with intrahepatic metastastasis and negatively regulates tumorigenesis.

Systemic antigen cross‐presented by liver sinusoidal endothelial cells induces liver‐specific CD8 T‐cell retention and tolerization

Nanette von Oppen, Anna Schurich, Silke Hegenbarth, Dirk Stabenow, Rene Tolba, Ralf Weiskirchen, Albert Geerts, Waldemar Kolanus, Percy Knolle, Linda Diehl – 27 April 2009 – Peripheral CD8 T‐cell tolerance can be generated outside lymphatic tissue in the liver, but the course of events leading to tolerogenic interaction of hepatic cell populations with circulating T‐cells remain largely undefined.

Bile salt–induced pro‐oxidant liver damage promotes transplanted cell proliferation for correcting Wilson disease in the Long‐Evans Cinnamon rat model

Brigid Joseph, Sorabh Kapoor, Michael L. Schilsky, Sanjeev Gupta – 27 April 2009 – Insights into disease‐specific mechanisms for liver repopulation are needed for cell therapy. To understand the efficacy of pro‐oxidant hepatic perturbations in Wilson disease, we studied Long‐Evans Cinnamon (LEC) rats with copper toxicosis under several conditions. Hepatocytes from healthy Long‐Evans Agouti (LEA) rats were transplanted intrasplenically into the liver.

Locating the stem cell niche and tracing hepatocyte lineages in human liver

Tariq G. Fellous, Shahriar Islam, Paul J. Tadrous, George Elia, Hemant M. Kocher, Satyajit Bhattacharya, Lisa Mears, Douglas M. Turnbull, Robert W. Taylor, Laura C. Greaves, Patrick F. Chinnery, Geoffery Taylor, Stuart A.C. McDonald, Nicholas A. Wright, Malcolm R. Alison – 27 April 2009 – We have used immunohistochemical and histochemical techniques to identify patches of hepatocytes deficient in the enzyme cytochrome c oxidase, a component of the electron transport chain and encoded by mitochondrial DNA (mtDNA).

Follow‐up of Chinese liver transplant recipients in Hong Kong

Sheung Tat Fan, Haibo Wang, Banny K. Lam – 27 April 2009 – The outcome of liver transplantation in China remains speculative. From 1998 to 2007, 177 adult Hong Kong patients underwent liver transplantation in China and were subsequently followed up at Queen Mary Hospital, Hong Kong. One hundred six (59.9%) patients had hepatocellular carcinoma (HCC). The grafts were probably derived from uncontrolled non–heart‐beating donors. The 1‐month mortality rate was 4.0%. The 1‐, 3‐, and 5‐year overall survival rates were 73.9%, 59.0%, and 53.9%, respectively.

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