Glucose dysregulation and hepatic steatosis in obese adolescents: Is there a link?

Anna M.G. Cali, Ana Mayra De Oliveira, Hyeonjin Kim, Shu Chen, Miguel Reyes‐Mugica, Sandra Escalera, James Dziura, Sara E. Taksali, Romy Kursawe, Melissa Shaw, Mary Savoye, Bridget Pierpont, R. Todd Constable, Sonia Caprio – 28 May 2009 – Fatty liver is increasingly common in obese adolescents. We determined its association with glucose dysregulation in 118 (37M/81F) obese adolescents of similar age and percent total fat. Fast‐magnetic resonance imaging (MRI) and simple MRI were used to quantify hepatic fat content and abdominal fat distribution.

No difference in clinical transplant outcomes for local and imported liver allografts

Richard S. Mangus, Jonathan A. Fridell, Rodrigo M. Vianna, Paul Y. Kwo, Paul Chestovich, Martin L. Milgrom, Marwan Kazimi, Edward F. Hollinger, Jay Thomas Read, A. Joseph Tector – 28 May 2009 – In the United States, liver allograft allocation is strictly regulated. Local centers have the first option to accept a donor liver; this is followed by regional allocation for those donor livers not used locally and then by national allocation for those donor livers not accepted regionally.

Graft rejection occurring in post–liver transplant patients receiving cytotoxic chemotherapy: A case series

Hui‐Hui Tan, M. Isabel Fiel, Juan del Rio Martin, Thomas D. Schiano – 28 May 2009 – Liver transplant recipients are known to be at increased risk for the development of de novo neoplasms or the recurrence of preexisting malignancies, and this is possibly related to the use of immunosuppressive medication. Little is known about the effects of cytotoxic chemotherapy on graft function after transplantation. A retrospective chart and pathology database review was undertaken to identify post–liver transplant patients developing rejection during chemotherapy.

Brain edema in liver failure: Basic physiologic principles and management

Fin Stolze Larsen, Julia Wendon – 6 May 2009 – In patients with severe liver failure, brain edema is a frequent and serious complication that may result in high intracranial pressure and brain damage. This short article focuses on basic physiologic principles that determine water flux across the blood‐brain barrier. Using the Starling equation, it is evident that both the osmotic and hydrostatic pressure gradients are imbalanced across the blood‐brain barrier in patients with acute liver failure. This combination will tend to favor cerebral capillary water influx to the brain.

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