Early high peak hepatitis C viral load levels independently predict hepatitis C–related liver failure post–liver transplantation

Nicholas A. Shackel, Jade Jamias, Wassim Rahman, Emilia Prakoso, Simone I. Strasser, David J. Koorey, Michael D. Crawford, Deborah J. Verran, James Gallagher, Geoffrey W. McCaughan – 26 June 2009 – The aim of this study was to examine the importance of the serum hepatitis C viral load within the first year post–liver transplant in determining posttransplant survival.

Unexplained and prolonged perioperative hypotension after orthotopic liver transplantation: Undiagnosed systemic mastocytosis

Darrin L. Willingham, Prith Peiris, Juan M. Canabal, Murli Krishna, Winston R. Hewitt, Timothy S. J. Shine, Lisa C. Arasi, Jaime Aranda‐Michel, Christopher B. Hughes, David J. Kramer – 26 June 2009 – Arterial vasodilation is common in end‐stage liver disease, and systemic hypotension often may develop, despite an increase in cardiac output. During the preparation for and the performance of orthotopic liver transplantation, expected and transient hypotension may be caused by induction agents, anesthetic agents, liver mobilization, or venous clamping.

Recurrent familial hypobetalipoproteinemia–induced nonalcoholic fatty liver disease after living donor liver transplantation

Noboru Harada, Yuji Soejima, Akinobu Taketomi, Tomoharu Yoshizumi, Hideaki Uchiyama, Toru Ikegami, Toshiharu Saibara, Takashi Nishizaki, Yoshihiko Maehara – 26 June 2009 – Familial hypobetalipoproteinemia (FHBL) is one of the causes of nonalcoholic steatohepatitis (NASH) and a codominant disorder. Patients heterozygous for FHBL may be asymptomatic, although they demonstrate low plasma levels of low‐density lipoprotein (LDL) cholesterol and apolipoprotein B.

Outcome of liver transplantation for drug‐induced acute liver failure in the United States: Analysis of the united network for organ sharing database

Ayse L. Mindikoglu, Laurence S. Magder, Arie Regev – 26 June 2009 – Acute liver failure (ALF) is an uncommon but potentially lethal drug‐related adverse effect that often leads to liver transplantation (LT) or death. A retrospective cohort study was performed with the United Network for Organ Sharing Standard Transplant Analysis and Research files. Recipients who underwent LT for drug‐induced acute liver failure (DIALF) from 1987 through 2006 were analyzed. A total of 661 patients transplanted for DIALF were included in the analysis.

Volumes of liver transplant and partial hepatectomy procedures are independently associated with lower postoperative mortality following resection for hepatocellular carcinoma

Geoffrey C. Nguyen, Nimisha P. Thuluvath, Dorry L. Segev, Paul J. Thuluvath – 26 June 2009 – Partial hepatectomy for hepatocellular carcinoma (HCC) is a high‐risk procedure, especially in the presence of portal hypertension. We assessed whether the volume of hospital liver transplant procedures was associated with lower in‐hospital mortality independently of the volume of partial hepatectomy procedures.

Extended right liver grafts obtained by an ex situ split can be used safely for primary and secondary transplantation with acceptable biliary morbidity

Atsushi Takebe, Harald Schrem, Bastian Ringe, Frank Lehner, Christian Strassburg, Juergen Klempnauer, Thomas Becker – 26 June 2009 – Split liver transplantation (SLT) is clearly beneficial for pediatric recipients. However, the increased risk of biliary complications in adult recipients of SLT in comparison with whole liver transplantation (WLT) remains controversial. The objective of this study was to investigate the incidence and clinical outcome of biliary complications in an SLT group using split extended right grafts (ERGs) after ex situ splitting in comparison with WLT in adults.

Hepatosplenic γδ T‐cell lymphoma after liver transplantation: Report of the first 2 cases and review of the literature

Philip R. Roelandt, Johan Maertens, Peter Vandenberghe, Chris Verslype, Tania Roskams, Raymond Aerts, Frederik Nevens, Daan Dierickx – 26 June 2009 – Hepatosplenic γδ T‐cell lymphoma is a rare lymphoproliferative disorder originating from natural killer–like Vδ1‐lymphocytes. This subtype has been described after different types of solid organ transplants. In this article, we describe the first 2 cases after liver transplantation.

Aprotinin and the risk of thrombotic complications after liver transplantation: A retrospective analysis of 1492 patients

Nienke Warnaar, Susan V. Mallett, John R. Klinck, Marieke T. de Boer, Nancy Rolando, Andrew K. Burroughs, Neville V. Jamieson, Keith Rolles, Robert J. Porte – 26 June 2009 – Aprotinin is an antifibrinolytic drug that reduces blood loss during orthotopic liver transplantation (OLT). Case reports have suggested that aprotinin may be associated with an increased risk of thromboembolic complications. Recent studies in cardiac surgery also have suggested a higher risk of renal failure and postoperative mortality.

A randomized pilot trial of oral branched‐chain amino acids in early cirrhosis: Validation using prognostic markers for pre–liver transplant status

Etsushi Kawamura, Daiki Habu, Hiroyasu Morikawa, Masaru Enomoto, Joji Kawabe, Akihiro Tamori, Hiroki Sakaguchi, Shigeru Saeki, Norifumi Kawada, Susumu Shiomi – 26 June 2009 – Because of the chronic shortage of liver donors, hepatologists are required to prolong the liver transplant waiting period by preserving the hepatic reserve of scheduled recipients. This study examined the effectiveness of oral branched‐chain amino acids (BCAAs), using outcome markers indicating pretransplant hepatic reserve.

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