Romain Parent, Xiaoyu Qu, Marie‐Anne Petit, Laura Beretta – 28 May 2009 – There is growing evidence that virus particles contain host cell proteins. These proteins may provide viruses with means to evade the immune system or with mechanisms for cell entry and release. A proteomic analysis performed on highly purified hepatitis C virus (HCV) J6/JFH virions identified the heat shock cognate protein 70 (HSC70) as part of the viral particles. These results were further validated via immunogold electron microscopy.

Anna M.G. Cali, Ana Mayra De Oliveira, Hyeonjin Kim, Shu Chen, Miguel Reyes‐Mugica, Sandra Escalera, James Dziura, Sara E. Taksali, Romy Kursawe, Melissa Shaw, Mary Savoye, Bridget Pierpont, R. Todd Constable, Sonia Caprio – 28 May 2009 – Fatty liver is increasingly common in obese adolescents. We determined its association with glucose dysregulation in 118 (37M/81F) obese adolescents of similar age and percent total fat. Fast‐magnetic resonance imaging (MRI) and simple MRI were used to quantify hepatic fat content and abdominal fat distribution.

Richard S. Mangus, Jonathan A. Fridell, Rodrigo M. Vianna, Paul Y. Kwo, Paul Chestovich, Martin L. Milgrom, Marwan Kazimi, Edward F. Hollinger, Jay Thomas Read, A. Joseph Tector – 28 May 2009 – In the United States, liver allograft allocation is strictly regulated. Local centers have the first option to accept a donor liver; this is followed by regional allocation for those donor livers not used locally and then by national allocation for those donor livers not accepted regionally.

Hui‐Hui Tan, M. Isabel Fiel, Juan del Rio Martin, Thomas D. Schiano – 28 May 2009 – Liver transplant recipients are known to be at increased risk for the development of de novo neoplasms or the recurrence of preexisting malignancies, and this is possibly related to the use of immunosuppressive medication. Little is known about the effects of cytotoxic chemotherapy on graft function after transplantation. A retrospective chart and pathology database review was undertaken to identify post–liver transplant patients developing rejection during chemotherapy.

William M. Lee, Anne M. Larson, Juan Arenas – 28 May 2009

Laurent Castera – 28 May 2009

Steven Schenker – 28 May 2009

Robert P. Myers, James C. Gregor, Paul J. Marotta – 21 May 2009

Akio Matsumoto, Hisashi Matsumoto, Hideto Inokuchi – 21 May 2009

Fin Stolze Larsen, Julia Wendon – 6 May 2009 – In patients with severe liver failure, brain edema is a frequent and serious complication that may result in high intracranial pressure and brain damage. This short article focuses on basic physiologic principles that determine water flux across the blood‐brain barrier. Using the Starling equation, it is evident that both the osmotic and hydrostatic pressure gradients are imbalanced across the blood‐brain barrier in patients with acute liver failure. This combination will tend to favor cerebral capillary water influx to the brain.