Xiaocong Chen, Becky M. Sebastian, Hui Tang, Megan M. McMullen, Armend Axhemi, Donald W. Jacobsen, Laura E. Nagy – 27 April 2009 – Chronic ethanol feeding decreases expression of adiponectin by adipocytes and circulating adiponectin. Adiponectin treatment during chronic ethanol feeding prevents liver injury in mice. Chronic ethanol feeding also increases oxidative and endoplasmic reticulum (ER) stress in adipose tissue.

Florin M. Selaru, Alexandru V. Olaru, Takatsugu Kan, Stefan David, Yulan Cheng, Yuriko Mori, Jian Yang, Bogdan Paun, Zhe Jin, Rachana Agarwal, James P. Hamilton, John Abraham, Christos Georgiades, Hector Alvarez, Perumal Vivekanandan, Wayne Yu, Anirban Maitra, Michael Torbenson, Paul J. Thuluvath, Gregory J. Gores, Nicholas F. LaRusso, Ralph Hruban, Stephen J. Meltzer – 27 April 2009 – Cholangiocarcinomas (CCAs) are aggressive cancers, with high mortality and poor survival rates.

Daniel J. Tenney, Ronald E. Rose, Carl J. Baldick, Kevin A. Pokornowski, Betsy J. Eggers, Jie Fang, Michael J. Wichroski, Dong Xu, Joanna Yang, Richard B. Wilber, Richard J. Colonno – 27 April 2009 – Patients with chronic hepatitis B virus (HBV) infection who develop antiviral resistance lose benefits of therapy and may be predisposed to further resistance. Entecavir (ETV) resistance (ETVr) results from HBV reverse transcriptase substitutions at positions T184, S202, or M250, which emerge in the presence of lamivudine (LVD) resistance substitutions M204I/V ± L180M.

Norah A. Terrault – 27 April 2009 – In successful antiviral therapy of hepatitis B, drug combinations, particularly combinations without cross‐resistance, can delay or prevent the emergence of drug‐resistant mutants. Because drug‐resistant mutants are archived and may limit future therapeutic options, prevention is important for long‐term therapeutic efficacy. Additionally, combining drugs may achieve synergistic or additive antiviral effects compared with single drug therapy.

Brent C. Taylor, Jian‐Min Yuan, Tatyana A. Shamliyan, Aasma Shaukat, Robert L. Kane, Timothy J. Wilt – 27 April 2009 – We systematically reviewed the literature on the extent to which population characteristics or clinical features predict groups of individuals likely to develop advanced liver disease or die from chronic infection with hepatitis B virus (HBV).

Darrell H. G. Crawford, Grant A. Ramm – 27 April 2009

W. Ray Kim – 27 April 2009 – Hepatitis B virus (HBV) remains an important cause of acute and chronic liver disease globally and in the United States. An encouraging trend is that the incidence of acute hepatitis B in the United States declined as much as 80% between 1987 and 2004, attributable to effective vaccination programs as well as universal precautions in needle use and in healthcare in general. Although encouraging, these decreases in acute infections have not translated into diminished prevalence or burden of chronic HBV infection.

Fawaz Almutairi, Theresa C. Peterson, Michele Molinari, Mark J. Walsh, Ian Alwayn, Kevork M. Peltekian – 27 April 2009 – Hypercholesterolemia is a common problem among transplant recipients. Despite package‐insert warnings about the potential side effects of the use of statins in patients with chronic liver disease, they are often prescribed for liver transplant recipients. Unlike statins, ezetimibe acts through inhibition of enterohepatic recirculation of lipids.

James D. Perkins – 27 April 2009

Alan F. Hofmann – 27 April 2009 – An informal review of the author's five decades of research on the chemistry and biology of bile acids in health and disease is presented. The review begins with a discussion of bile acid structure and its remarkable diversity in vertebrates. Methods for tagging bile acids with tritium for metabolic or transport studies are summarized. Bile acids solubilize polar lipids in mixed micelles; progress in elucidating the structure of the mixed micelle is discussed.