Doris Duller, Daniela Kniepeiss, Carolin Lackner, Rupert H. Portugaller, Estrella Jakoby, Silvia Schaffellner, Philipp Stiegler, Kahn Judith, Helmut Mueller, Regina Roller, Karl Heinz Tscheliessnigg, Florian Iberer – 27 April 2009
Mohamed Hassan, Denis Selimovic, Hanan Ghozlan, Ola Abdel‐kader – 27 April 2009 – Chronic hepatitis C virus (HCV) infection is associated with the production of serum cytokines, including transforming growth factor (TGF)‐β2. Despite the occurrence of hepatic angiogenesis in liver conditions, the role of HCV proteins in this context is currently unknown.
Juliane I. Beier, James P. Luyendyk, Luping Guo, Claudia von Montfort, Donald E. Staunton, Gavin E. Arteel – 27 April 2009 – The early stages of alcohol‐induced liver injury involve chronic inflammation. Whereas mechanisms by which this effect is mediated are not completely understood, it is hypothesized that enhanced sensitivity to circulating lipopolysaccharide (LPS) contributes to this process. It has recently been shown that ethanol induces activation of plasminogen activator inhibitor‐1 (PAI‐1).
Marc‐Oliver Riener, Frank Stenner, Heike Liewen, Christopher Soll, Stefan Breitenstein, Bernhard Cornelius Pestalozzi, Panagiotis Samaras, Nicole Probst‐Hensch, Claus Hellerbrand, Beat Müllhaupt, Pierre‐Alain Clavien, Marcus Bahra, Peter Neuhaus, Peter Wild, Florian Fritzsche, Holger Moch, Wolfram Jochum, Glen Kristiansen – 27 April 2009 – Hepatocellular carcinomas (HCCs) and bile duct carcinomas (BDCs) have a poor prognosis. Therefore, surveillance strategies including sensitive and specific serum markers for early detection are needed.
Saleem Kamili, Vitini Sozzi, Geoff Thompson, Katie Campbell, Christopher M. Walker, Stephen Locarnini, Krzysztof Krawczynski – 27 April 2009 – Hepatitis B virus (HBV) mutants resistant to treatment with nucleoside or nucleotide analogs and those with the ability to escape from HBV‐neutralizing antibody have the potential to infect HBV‐vaccinated individuals. To address this potential serious public health challenge, we tested the efficacy of immunity induced by a commercial hepatitis B vaccine against a tissue culture‐derived, clonal HBV polymerase mutant in HBV seronegative chimpanzees.
Robert P. Myers, Abdel Aziz M. Shaheen – 27 March 2009
Natalia A. Osna, Ronda L. White, Geoffrey M. Thiele, Terrence M. Donohue – 27 March 2009 – The proteasome is a major enzyme that cleaves proteins for antigen presentation. Cleaved peptides traffic to the cell surface, where they are presented in the context of major histocompatibility complex (MHC) class I. Recognition of these complexes by cytotoxic T lymphocytes is crucial for elimination of cells bearing “nonself” proteins. Our previous studies revealed that ethanol suppresses proteasome function in ethanol‐metabolizing liver cells.
Andrea Perra, Marta Anna Kowalik, Monica Pibiri, Giovanna M. Ledda‐Columbano, Amedeo Columbano – 27 March 2009 – Triiodothyronine (T3), through interaction with its intracellular thyroid hormone receptors (TRs), influences various physiological functions, including metabolism, development, and growth. We investigated the effect of T3 and the selective TR‐β agonist GC‐1 in two models of hepatocarcinogenesis. Preneoplastic lesions were induced in F‐344 rats via a single dose of diethylnitrosamine, followed by a choline‐deficient (CD) diet for 10 weeks.
Pedro Zapater, Rubén Francés, Jose Such – 27 March 2009