Manal M. Hassan, Ahmed Kaseb, Donghui Li, Yehuda Z. Patt, Jean‐Nicolas Vauthey, Melanie B. Thomas, Steven A. Curley, Margaret R. Spitz, Steven I. Sherman, Eddie K. Abdalla, Marta Davila, Richard D. Lozano, Deena M. Hassan, Wenyaw Chan, Thomas D. Brown, James L. Abbruzzese – 27 April 2009 – Thyroid hormones play an essential role in lipid mobilization, lipid degradation, and fatty acid oxidation.

Noémi K. M. Van Hul, Jorge Abarca‐Quinones, Christine Sempoux, Yves Horsmans, Isabelle A. Leclercq – 27 April 2009 – In chronic liver injury, liver progenitor cells (LPCs) proliferate in the periportal area, migrate inside the lobule, and undergo further differentiation. This process is associated with extracellular matrix (ECM) remodeling. We analyzed LPC expansion and matrix accumulation in a choline‐deficient, ethionine‐supplemented (CDE) model of LPC proliferation. After day 3, CDE induced collagen deposits in the periportal area.

Elke Hennes, Christoph Schramm, Ansgar Lohse – 27 April 2009

Edward C. Doo, Jay H. Hoofnagle, Griffin P. Rodgers – 27 April 2009

Naoki Hama, Yuka Yanagisawa, Keizo Dono, Shogo Kobayashi, Shigeru Marubashi, Hiroaki Nagano, Koji Umeshita, Shinya Watanabe, Yasuo Uchiyama, Morito Monden – 27 April 2009 – Acute cellular rejection (ACR) is still a major problem in organ transplantation, and its genetic and molecular mechanisms remain poorly understood. We used DNA microarrays to investigate the gene expression profiles in ACR. We hypothesized that changes of gene expression in grafts could also be detected in peripheral blood leukocytes.

Andrew L. Singer, Jamye E. Locke, Zoe A. Stewart, Bonnie E. Lonze, James P. Hamilton, Jennifer R. Scudiere, Robert A. Anders, Russell P. Rother, Robert A. Brodsky, Andrew M. Cameron – 27 April 2009 – Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hemolytic anemia caused by somatic mutations in the phosphatidylinositol glycan‐complementation class A gene and the resulting absence of a key complement regulatory protein, CD59.

Joseph Ahn, Stanley Cohen – 27 April 2009

Emanuel K. Manesis – 27 April 2009

Ogyi Park, Won‐IL Jeong, Lei Wang, Hua Wang, Zhe‐Xiong Lian, M. Eric Gershwin, Bin Gao – 27 April 2009 – Liver fibrosis is a common scarring response to all forms of chronic liver injury and is always associated with inflammation that contributes to fibrogenesis. Although a variety of cell populations infiltrate the liver during inflammation, it is generically clear that CD8 T lymphocytes promote while natural killer (NK) cells inhibit liver fibrosis. However, the role of invariant natural killer T (iNKT) cells, which are abundant in the liver, in hepatic fibrogenesis, remains obscure.

Wan‐Jen Yang, Ching‐Ju Chang, Shiou‐Hwei Yeh, Wei‐Hsiang Lin, Sheng‐Han Wang, Ting‐Fen Tsai, Ding‐Shinn Chen, Pei‐Jer Chen – 27 April 2009 – Hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) occurs predominantly in men. By enhancing the transcriptional activity of the androgen receptor (AR) gene in a ligand‐dependent manner, the HBV X protein (HBx) might contribute to this disparity between sexes. To dissect the mechanisms underlying HBx‐enhanced AR transactivation, we investigated the effect of HBx on two critical steps in the regulation of ligand‐stimulated AR activities.