The need for novel and interesting data in liver cancer research
Jordi Bruix, Keith Lindor – 20 November 2009
Diagnostic power of fibroscan in predicting liver fibrosis in nonalcoholic fatty liver disease
Anna Alisi, Massimo Pinzani, Valerio Nobili – 20 November 2009
Cooperation of innate and adaptive immunity in the pathogenesis of biliary atresia: There's a killer on the run
Alexandra Sharland, Mark D. Gorrell – 20 November 2009
In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice
Evgeny Chichelnitskiy, Alexandros Vegiopoulos, Mauricio Berriel Diaz, Anja Ziegler, Anna Kleiman, Alexander Rauch, Jan Tuckermann, Stephan Herzig – 20 November 2009 – In mammals, proper maintenance of blood glucose levels within narrow limits is one of the most critical prerequisites for healthy energy homeostasis and body function. Consequently, hyper‐ and hypoglycemia represent hallmarks of severe metabolic pathologies, including type II diabetes and acute sepsis, respectively.
Adenosine triphosphatase pontin is overexpressed in hepatocellular carcinoma and coregulated with reptin through a new posttranslational mechanism
Valérie Haurie, Ludovic Ménard, Alexandra Nicou, Christian Touriol, Philippe Metzler, Jérémy Fernandez, Danièle Taras, Patrick Lestienne, Charles Balabaud, Paulette Bioulac‐Sage, Hervé Prats, Jessica Zucman‐Rossi, Jean Rosenbaum – 20 November 2009 – Reptin and Pontin are related ATPases associated with stoichiometric amounts in several complexes involved in chromatin remodeling, transcriptional regulation, and telomerase activity. We found that Reptin was up‐regulated in hepatocellular carcinoma (HCC) and that down‐regulation of Reptin led to growth arrest.
Spectrum of neurocognitive impairment in cirrhosis: Implications for the assessment of hepatic encephalopathy
Jasmohan S. Bajaj, James B. Wade, Arun J. Sanyal – 20 November 2009
Role of β3‐adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis
Jonel Trebicka, Martin Hennenberg, Andrea Schulze Pröbsting, Wim Laleman, Sabine Klein, Michaela Granzow, Frederik Nevens, Johan Zaagsma, Jörg Heller, Tilman Sauerbruch – 20 November 2009 – Increased intrahepatic resistance and splanchnic blood flow cause portal hypertension in liver cirrhosis. Nonselective β‐adrenoceptor (β‐AR) antagonists have beneficial effects on hyperdynamic circulation and are in clinical use. In this context, the role of the β3‐AR is undefined. Here we investigated their expression and role in portal hypertension in patients and rats with liver cirrhosis.
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Dhiraj Tripathi, Peter C. Hayes – 20 November 2009
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Manuel Romero‐Gómez, Ana Fernández‐Palacín, Conrado M. Fernández‐Rodriguez – 20 November 2009
Disruptions of occludin and claudin‐5 in brain endothelial cells in vitro and in brains of mice with acute liver failure
Feng Chen, Norifumi Ohashi, Wensheng Li, Christopher Eckman, Justin H. Nguyen – 20 November 2009 – Brain edema in acute liver failure (ALF) remains lethal. The role of vasogenic mechanisms of brain edema has not been explored. We previously demonstrated that matrix metalloproteinase‐9 (MMP‐9) contributes to the pathogenesis of brain edema. Here, we show that MMP‐9 mediates disruptions in tight junction (TJ) proteins in vitro and in brains of mice with ALF.