Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA‐21 up‐regulation in hepatocytes

Manlio Vinciguerra, Antonino Sgroi, Christelle Veyrat‐Durebex, Laura Rubbia‐Brandt, Leo H. Buhler, Michelangelo Foti – 27 March 2009 – Phosphatase and tensin homolog (PTEN) is a regulator of phosphoinositide 3‐kinase signaling and an important tumor suppressor mutated/deleted in human cancers. PTEN deletion in the liver leads to insulin resistance, steatosis, inflammation, and cancer.

Computer‐assisted image analysis of liver collagen: Relationship to Ishak scoring and hepatic venous pressure gradient

Vincenza Calvaruso, Andrew Kenneth Burroughs, Richard Standish, Pinelopi Manousou, Federica Grillo, Gioacchino Leandro, Sergio Maimone, Maria Pleguezuelo, Ilias Xirouchakis, Gian Piero Guerrini, David Patch, Dominic Yu, James O'Beirne, Amar Paul Dhillon – 27 March 2009 – Histopathological scoring of disease stage uses descriptive categories without measuring the amount of fibrosis. Collagen, the major component of fibrous tissue, can be quantified by computer‐assisted digital image analysis (DIA) using histological sections.

Hepatitis B virus suppresses toll‐like receptor–mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

Jun Wu, Zhongji Meng, Min Jiang, Rongjuan Pei, Martin Trippler, Ruth Broering, Agnes Bucchi, Jan‐Peter Sowa, Ulf Dittmer, Dongliang Yang, Michael Roggendorf, Guido Gerken, Mengji Lu, Joerg F. Schlaak – 27 March 2009 – We have previously shown that Toll‐like receptor (TLR)‐activated murine nonparenchymal liver cells [(NPC); Kupffer cells (KC), liver sinusoidal endothelial cells (LSEC)] can suppress hepatitis B virus (HBV) replication. Therefore, the aim of this study was to investigate whether HBV has the ability to counteract the TLR‐mediated control of its replication.

Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)‐β signaling from tumor suppression to oncogenesis in early chronic hepatitis B

Miki Murata, Koichi Matsuzaki, Katsunori Yoshida, Go Sekimoto, Yoshiya Tahashi, Shigeo Mori, Yoshiko Uemura, Noriko Sakaida, Junichi Fujisawa, Toshihito Seki, Kazuki Kobayashi, Koutaro Yokote, Kazuhiko Koike, Kazuichi Okazaki – 27 March 2009 – Hepatitis B virus X (HBx) protein is suspected to participate in oncogenesis during chronic hepatitis B progression. Transforming growth factor β (TGF‐β) signaling involves both tumor suppression and oncogenesis.

An early complement‐dependent and TLR‐4–independent phase in the pathogenesis of ethanol‐induced liver injury in mice

Sanjoy Roychowdhury, Megan R. McMullen, Michele T. Pritchard, Amy G. Hise, Nico van Rooijen, M. Edward Medof, Abram B. Stavitsky, Laura E. Nagy – 27 March 2009 – The innate immune system has been implicated in the pathogenesis of alcoholic liver disease. Although innate immunity is usually considered an early response to injury, previous work implicating innate immunity in ethanol‐induced liver injury focuses primarily on long‐term ethanol exposure.

Liver X receptor mediates hepatitis B virus X protein–induced lipogenesis in hepatitis B virus–associated hepatocellular carcinoma

Tae‐Young Na, Young Kee Shin, Kyung Jin Roh, Shin‐Ae Kang, Il Hong, Sae Jin Oh, Je Kyung Seong, Cheol Keun Park, Yoon La Choi, Mi‐Ock Lee – 27 March 2009 – Although hepatitis B virus X protein (HBx) has been implicated in abnormal lipid metabolism in hepatitis B virus (HBV)–associated hepatic steatosis, its underlying molecular mechanism remains unclear. Liver X receptor (LXR) plays an important role in regulating the expression of genes involved in hepatic lipogenesis. Here we demonstrate that LXRα and LXRβ mediate HBV‐associated hepatic steatosis.

Subscribe to