Effect of angiotensin II and bradykinin inhibition in rat reduced‐size liver transplantation

Susagna Padrissa‐Altés, Rosa Franco‐Gou, Olivier Boillot, Anna Serafín, Antoni Rimola, Vicente Arroyo, Joan Rodés, Carmen Peralta, Joan Roselló‐Catafau – 25 February 2009 – This study examined whether angiotensin II (Ang II) blockers [Ang II type I receptor antagonist, Ang II type II receptor antagonist, and angiotensin converting enzyme (ACE) inhibitor] could reduce hepatic injury and improve regeneration in reduced‐size orthotopic liver transplantation (ROLT) and whether the beneficial effects of ischemic preconditioning (PC) in ROLT could be explained by changes in Ang II.

A re‐evaluation of the risk factors for the recurrence of primary sclerosing cholangitis in liver allografts

Edward Alabraba, Peter Nightingale, Bridget Gunson, Stefan Hubscher, Simon Olliff, Darius Mirza, James Neuberger – 25 February 2009 – Previously, we have found that the absence of the colon after liver transplantation (LT) protects the patient from recurrent primary sclerosing cholangitis (rPSC). As our previous observation has not been confirmed in other series, we have reviewed our cohort of patients grafted for primary sclerosing cholangitis (PSC) with greater numbers and longer follow‐up to reassess the rate, consequences, and risk factors for rPSC.

Microdialysis monitoring of porcine liver metabolism during warm ischemia with arterial and portal clamping

Johan Ungerstedt, Greg Nowak, Urban Ungerstedt, Bo‐Göran Ericzon – 25 February 2009 – Early detection of vascular complications following liver surgery is crucial. In the present study, intrahepatic microdialysis was used for continuous monitoring of porcine liver metabolism during occlusion of either the portal vein or the hepatic artery. Our aim was to assess whether microdialysis can be used to detect impaired vascular inflow by metabolic changes in the liver. Changes in metabolite concentrations in the hepatic interstitium were taken as markers for metabolic changes.

Hepatitis B virus–specific CD4 T cell immunity after liver transplantation for chronic hepatitis B

Ying Luo, Chung Mau Lo, Cindy K. Cheung, George K. Lau, John Wong – 25 February 2009 – Cellular immunity plays an important role in the long‐term control of hepatitis B virus (HBV) infection. We studied the changes in HBV‐specific CD4 T cell immunity after orthotopic liver transplantation (OLT) for chronic hepatitis B under antiviral prophylaxis.

Techniques of cardiac output measurement during liver transplantation: Arterial pulse wave versus thermodilution

Peter Nissen, Johannes J. Van Lieshout, Srdan Novovic, Morten Bundgaard‐Nielsen, Niels H. Secher – 25 February 2009 – In this study, we compared continuous cardiac output (CO) obtained from the femoral arterial pressure by simulation of an aortic input impedance model [model‐simulated cardiac output (MCO)] to thermodilution cardiac output (TDCO) determined by bolus injection during liver transplantation. Both variables were measured in 39 adult patients (13 females) every 10th minute during liver transplant surgery.

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