Napoleon Waszkiewicz, Sławomir Dariusz Szajda, Anna Zalewska, Beata Konarzewska, Agata Szulc, Alina Kȩpka, Krzysztof Zwierz – 29 October 2009

29 October 2009

Carlo Pedrolli, Emanuele Cereda – 29 October 2009

Michael Charlton – 29 October 2009

En‐Qiang Chen, Hong Tang – 29 October 2009

Katsunori Yoshida, Guo‐Xiang Yang, Weici Zhang, Masanobu Tsuda, Koichi Tsuneyama, Yuki Moritoki, Aftab A. Ansari, Kazuichi Okazaki, Zhe‐Xiong Lian, Ross L. Coppel, Ian R. Mackay, M.

Andre Boonstra, Luc J. W. van der Laan, Thomas Vanwolleghem, Harry L. A. Janssen – 29 October 2009 – Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease. The majority of infected individuals develop a persistent infection, which is associated with a high risk of liver cirrhosis and hepatocellular carcinoma. Since its discovery 20 years ago, progress in our understanding of this virus has been suboptimal due to the lack of good model systems.

Xiuda Shen, Yue Wang, Feng Gao, Feng Ren, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski, Yuan Zhai – 29 October 2009 – Although the role of CD4 T cells in tissue inflammation and organ injury resulting from ischemia and reperfusion injury (IRI) has been well documented, it remains unclear how CD4 T cells are activated and function in the absence of a specific antigen (Ag). We used a murine liver warm IRI model to determine first whether de novo Ag‐specific CD4 T cell activation was required and then what its functional mechanism was.

Jaime Chu, Kirsten C. Sadler – 29 October 2009 – There is significant overlap in the genes and pathways that control liver development and those that regulate liver regeneration, hepatic progenitor cell expansion, response to injury, and cancer. Additionally, defects in liver development may underlie some congenital and perinatal liver diseases. Thus, studying hepatogenesis is important for understanding not only how the liver forms, but also how it functions.

Anthony J. Demetris – 29 October 2009 – Key Points