Gustav Paumgartner – 26 March 2010 – A review is presented of Gustav Paumgartner's five decades of research and practice in hepatology focusing on biliary physiology and disease. It begins with studies of the excretory function of the liver including hepatic uptake of indocyanine green, bilirubin, and bile acids. The implications of these studies for diagnosis and understanding of liver diseases are pointed out. From there, the path of scientific research leads to investigations of hepatobiliary bile acid transport and the major mechanisms of bile formation.

Leander Blaas, Jan‐Wilhelm Kornfeld, Daniel Schramek, Monica Musteanu, Gernot Zollner, Judith Gumhold, Franziska van Zijl, Doris Schneller, Harald Esterbauer, Gerda Egger, Markus Mair, Lukas Kenner, Wolfgang Mikulits, Robert Eferl, Richard Moriggl, Josef Penninger, Michael Trauner, Emilio Casanova – 26 March 2010 – Growth hormone (GH) resistance and low serum levels of insulinlike growth factor 1 (IGF‐1) are common features in human liver fibrosis and cirrhosis.

Arun Thenappan, Ying Li, Krit Kitisin, Asif Rashid, Kirti Shetty, Lynt Johnson, Lopa Mishra – 26 March 2010 – Adult hepatic progenitor cells are activated during regeneration when hepatocytes and bile duct epithelium are damaged or unable to proliferate. On the basis of its role as a tumor suppressor and in the potential malignant transformation of stem cells in hepatocellular carcinoma, we investigated the role of key transforming growth factor beta (TGF‐β) signaling components, including the Smad3 adaptor protein β2‐Spectrin (β2SP), in liver regeneration.

Carina Riediger, Michael W. Müller, Christoph W. Michalski, Norbert Hüser, Tibor Schuster, Jörg Kleeff, Helmut Friess – 23 March 2010 – The routine use of a T‐tube in reconstruction of the biliary tree during orthotopic liver transplantation (OLT) is controversial. A systematic review of the literature on the use of a T‐tube in reconstruction of the biliary tree was performed. Retrospective studies were only reviewed, whereas prospective randomized studies were included in the meta‐analysis. An analysis of 196 studies revealed that 91 studies investigated the use of a T‐tube in OLT.

Sammy Saab, Douglas R. Hunt, Michael A. Stone, Amy McClune, Myron J. Tong – 23 March 2010 – Antiviral therapy for the treatment of hepatitis C virus (HCV) infection is used before and after liver transplantation. The objective of this study was to determine the most cost‐effective timing for pegylated interferon/ribavirin therapy in patients with advanced liver disease infected with genotype 1 HCV.

Karl‐Heinz Schulz, Sylvia Kroencke – 8 March 2010

Benjamin L. Shneider, Mark S. Roberts, Kyle Soltys – 8 March 2010

Dorry L. Segev, Robert A. Montgomery – 8 March 2010

Pinelopi Manousou, AP Dhillon, Andrew K Burroughs – 8 March 2010

Allan M. Concejero, Chee‐Chien Yong, Chao‐Long Chen, Hung‐I Lu, Chih‐Chi Wang, Shih‐Ho Wang, Yueh‐Wei Liu, Chin‐Hsiang Yang, Yu‐Fan Cheng, Bruno Jawan – 8 March 2010 – Our objectives were to define the incidence and etiology of solitary pulmonary nodules (SPNs) in patients undergoing living donor liver transplantation (LDLT), describe a diagnostic approach to the management of SPNs in LDLT, and define the impact of SPNs on the overall survival of adult LDLT recipients.