Impact of the hepatitis B virus genotype on pre– and post–liver transplantation outcomes

Paul Gaglio, Sundeep Singh, Bulent Degertekin, Michael Ishitani, Munira Hussain, Robert Perrillo, Anna S. Lok – 29 September 2008 – Emerging data suggest that the hepatitis B virus (HBV) genotype and the precore and core promoter variants impact the outcome of orthotopic liver transplantation (OLT) for hepatitis B. The aim of this study was to determine if there is a correlation between HBV genotype, precore and core promoter variants, and pre‐ and post‐OLT outcomes.

Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis

Hye Jung Baek, Sung Chul Lim, Krit Kitisin, Wilma Jogunoori, Yi Tang, M. Blair Marshall, Bibhuti Mishra, Tae Hyun Kim, Kwan Ho Cho, Sang Soo Kim, Lopa Mishra – 26 September 2008 – We have previously demonstrated that 40%‐70% of elf+/− mice spontaneously develop hepatocellular cancer (HCC) within 15 months, revealing the importance of the transforming growth factor‐beta (TGF‐β) signaling pathway in suppressing tumorigenesis in the liver.

Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models

Elizabeth P. Newberry, Susan M. Kennedy, Yan Xie, Jianyang Luo, Susan E. Stanley, Clay F. Semenkovich, Roseanne M. Crooke, Mark J. Graham, Nicholas O. Davidson – 26 September 2008 – Liver regeneration is impaired following partial hepatectomy (PH) in mice with genetic obesity and hepatic steatosis and also in wild‐type mice fed a high‐fat diet. These findings contrast with other data showing that liver regeneration is impaired in mice in which hepatic lipid accumulation is suppressed by either pharmacologic leptin administration or by disrupted glucocorticoid signaling.

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