Mingyan Zhou, Aimin Xu, Paul K. H. Tam, Karen S. L. Lam, Lawrence Chan, Ruby L. C. Hoo, Jing Liu, Kim H. M. Chow, Yu Wang – 26 September 2008 – Adiponectin is an adipocyte‐derived hormone with a wide range of beneficial effects on obesity‐related medical complications. Numerous epidemiological investigations in diverse ethnic groups have identified a lower adiponectin level as an independent risk factor for nonalcoholic fatty liver diseases and liver dysfunctions.

James Rochon, Petr Protiva, Leonard B. Seeff, Robert J. Fontana, Suthat Liangpunsakul, Paul B. Watkins, Timothy Davern, John G. McHutchison, Drug‐Induced Liver Injury Network (DILIN) – 26 September 2008 – The Roussel Uclaf Causality Assessment Method (RUCAM) was developed to quantify the strength of association between a liver injury and the medication implicated as causing the injury. However, its reliability in a research setting has never been fully explored.

Ze‐Zhou Song – 26 September 2008

Melania Manco, GianFranco Bottazzo – 26 September 2008

Marco Senzolo, David Patch, Diego Miotto, Cecilia Ferronato, Evangelos Cholongitas, Andrew K. Burroughs – 26 September 2008

Alessandro Principe, Pedro Melgar‐Lesmes, Guillermo Fernández‐Varo, Luis Ruiz del Arbol, Josefa Ros, Manuel Morales‐Ruiz, Mauro Bernardi, Vicente Arroyo, Wladimiro Jiménez – 26 September 2008 – Apelin is a peptide that plays an important role in heart physiology and pathophysiology, inflammation, and angiogenesis. We evaluated whether the endogenous apelin system is involved in the pathogenesis of the hepatic remodeling and cardiovascular and renal complications occurring in advanced liver disease.

Hila Barash, Eitan Gross, Yifat Edrei, Orit Pappo, Gadi Spira, Israel Vlodavsky, Eithan Galun, Idit Matot, Rinat Abramovitch – 26 September 2008 – Liver diseases and regeneration are associated with hemodynamic changes denoting pathological alterations. Determining and monitoring physiological and pathological liver changes is essential for diagnostic and therapeutic objectives. Our aim was to determine the feasibility of functional magnetic resonance imaging (fMRI) during hypercapnia and hyperoxia for monitoring liver pathology.

Istvan Hritz, Arumugam Velayudham, Angela Dolganiuc, Karen Kodys, Pranoti Mandrekar, Evelyn Kurt‐Jones, Gyongyi Szabo – 26 September 2008 – Toll‐like receptors (TLRs) expressed on both immune cells and hepatocytes recognize microbial danger signals and regulate immune responses. Previous studies showed that TLR9 and TLR2 mediate Propionibacterium acnes–induced sensitization to lipopolysaccharide‐triggered acute liver injury in mice. Ligand‐specific activation of TLR2 and TLR9 are dependent on the common TLR adaptor, myeloid differentiation factor 88 (MyD88).

Geoffrey C. Nguyen, Justina Sam, Paul J. Thuluvath – 26 September 2008 – Acute liver injury (ALI) following acetaminophen overdose (AO) occurs in less than 10% of cases, but that risk is increased among alcoholics and those with chronic alcoholic liver disease. We sought to assess whether coexistent hepatitis C virus (HCV) infection potentiated the hepatotoxic effects of acetaminophen. We queried the Nationwide Inpatient Sample (1998‐2005), a 20% sample of U.S.

Daniel Gotthardt, Heiko Runz, Verena Keitel, Christine Fischer, Christa Flechtenmacher, Michael Wirtenberger, Karl Heinz Weiss, Sandra Imparato, Annika Braun, Kari Hemminki, Wolfgang Stremmel, Franz Rüschendorf, Adolf Stiehl, Ralf Kubitz, Barbara Burwinkel, Peter Schirmacher, A. S. Knisely, Johannes Zschocke, Peter Sauer – 26 September 2008 – Cholestatic liver disease (CLD) is a major cause of progressive liver damage and liver failure. Several forms of biliary cirrhosis are caused by mutations in specific genes.