Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis

Hye Jung Baek, Sung Chul Lim, Krit Kitisin, Wilma Jogunoori, Yi Tang, M. Blair Marshall, Bibhuti Mishra, Tae Hyun Kim, Kwan Ho Cho, Sang Soo Kim, Lopa Mishra – 26 September 2008 – We have previously demonstrated that 40%‐70% of elf+/− mice spontaneously develop hepatocellular cancer (HCC) within 15 months, revealing the importance of the transforming growth factor‐beta (TGF‐β) signaling pathway in suppressing tumorigenesis in the liver.

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