Hemodynamic and metabolic efficacy of dopamine versus norepinephrine in a brain‐dead swine model

Ahmed Zaky, Ernesto A. Pretto, Steven A. Earle, Emanuele Piraccini, Jennifer E. Zuccarelli, Kristopher L. Arheart, Kenneth G. Proctor – 28 August 2008 – We tested the hypothesis that hepatosplanchnic and systemic hemodynamics are improved with equi‐effective doses of dopamine (DA) versus norepinephrine (NE) in a brain‐dead swine model. Pigs (n = 18) were anesthetized and ventilated. Brain death was induced by epidural balloon inflation, hypoventilation, and hypoxia. After 30 minutes, mechanical ventilation was restored without anesthesia.

Effect of hospital volume and teaching status on outcomes of acute liver failure

Ashwin N. Ananthakrishnan, Emily L. McGinley, Kia Saeian – 28 August 2008 – Acute liver failure (ALF) often requires multidisciplinary support. Higher hospital volumes have been associated with better outcomes for surgical procedures, but whether such a relationship exists for ALF has not been explored previously. In this study, our aim was to examine if hospital volume affects mortality from ALF.

Treatment of hepatocellular carcinoma by AdAFPep/rep, AdAFPep/p53, and 5‐fluorouracil in mice

Tamotsu Sagawa, Yasuyuki Yamada, Minoru Takahashi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Junki Fukaura, Satoshi Iyama, Tsutomu Sato, Koji Miyanishi, Takuya Matsunaga, Tetsuji Takayama, Junji Kato, Katsunori Sasaki, Hirofumi Hamada, Yoshiro Niitsu – 28 August 2008 – Although conditionally replicable adenovirus (CRAd) has been used in the clinical treatment of hepatocellular carcinoma (HCC), it suffers from the inherent drawback of having relatively low antitumor activity. Here, we have sought to overcome this drawback.

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