Debbie L. Shawcross, Gavin A. K. Wright, Vanessa Stadlbauer, Stephen J. Hodges, Nathan A. Davies, Caroline Wheeler‐Jones, Andrew A. Pitsillides, Rajiv Jalan – 26 September 2008 – Hyperammonemia is a feature of liver failure, which is associated with increased risk of infection. The aims of the present study were to determine in vitro, in rats fed an ammoniagenic diet and in patients with cirrhosis, whether induction of hyperammonemia results in neutrophil dysfunction.

Josep M. Llovet, Jordi Bruix – 26 September 2008 – Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor with several genomic alterations. There is evidence of aberrant activation of several signaling cascades such as epidermal growth factor receptor (EGFR), Ras/extracellular signal‐regulated kinase, phosphoinositol 3‐kinase/mammalian target of rapamycin (mTOR), hepatocyte growth factor/mesenchymal‐epithelial transition factor, Wnt, Hedgehog, and apoptotic signaling. Recently a multikinase inhibitor, sorafenib, has shown survival benefits in patients with advanced HCC.

M. Eric Gershwin, Ian R. Mackay – 26 September 2008

Alastair O'Brien, Roger Williams – 26 September 2008

Michael W. Fried, Donald M. Jensen, Maribel Rodriguez‐Torres, Lisa M. Nyberg, Adrian M. Di Bisceglie, Timothy R. Morgan, Paul J. Pockros, Amy Lin, Lisa Cupelli, Frank Duff, Ka Wang, David R. Nelson – 26 September 2008 – Treatment response remains suboptimal for many patients with chronic hepatitis C, particularly those with genotype 1 and high levels of viremia. The efficacy of high‐dose regimens of peginterferon alfa‐2a and ribavirin was compared with conventional dose regimens in patients with features predicting poor treatment responses.

Pantxika Bellecave, Darius Moradpour – 26 September 2008

Gregory J. Dore, Paul S. Haber – 26 September 2008

24 September 2008

24 September 2008

24 September 2008