The extent of vacuolation in non–heart‐beating porcine donor liver grafts prior to transplantation predicts their viability

Diethard Monbaliu, Louis Libbrecht, Rita De Vos, Katrien Vekemans, Hugo Walter, Qiang Liu, Veerle Heedfeld, Vera Goossens, Jacques Pirenne, Tania Roskams – 28 August 2008 – Livers exposed to prolonged warm ischemia (WI), such as those from non–heart‐beating donors (NHBDs), are at higher risk of primary graft nonfunction (PNF). In a pig model of liver transplantation (LTx) from NHBDs, hepatocellular vacuolation, focal hepatocyte dropout, congestion, and sinusoidal dilatation appeared on biopsies taken after exposure to WI.

Liver transplantation for autoimmune hepatitis and the success of aggressive corticosteroid withdrawal

Jeffrey Campsen, Michael A. Zimmerman, James F. Trotter, Michael Wachs, Thomas Bak, Tracy Steinberg, Maria Kaplan, Franklin Wright, Igal Kam – 28 August 2008 – Our center has attempted to minimize corticosteroid (CS) use in all of our orthotopic liver transplantation (OLT) recipients. Because patients with autoimmune hepatitis (AIH) typically require CSs after transplantation, we reviewed our experience in this cohort of patients to determine (1) patient outcomes including recurrent disease and (2) long‐term requirements for CS use in AIH patients.

Improvement of impaired albumin binding capacity in acute‐on‐chronic liver failure by albumin dialysis

Sebastian Klammt, Steffen R. Mitzner, Jan Stange, Jan Loock, Uwe Heemann, Jörg Emmrich, Emil C. Reisinger, Reinhard Schmidt – 28 August 2008 – Extracorporeal albumin dialysis (ECAD) enables the elimination of albumin bound substances and is used as artificial liver support system. Albumin binding function for the benzodiazepine binding site specific marker Dansylsarcosine was estimated in plasma samples of 22 patients with cirrhosis and hyperbilirubinaemia (ECAD: n = 12; control: n = 10) during a period of 30 days in a randomized controlled clinical ECAD trial.

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