Risk factors and impact of chronic obstructive pulmonary disease in candidates for liver transplantation

Debbie Rybak, Michael B. Fallon, Michael J. Krowka, Robert S. Brown, Jenna Reinen, Linda Stadheim, Dorothy Faulk, Carrie Nielsen, Nadine Al‐Naamani, Kari Roberts, Steven Zacks, Ted Perry, James Trotter, Steven M. Kawut, Pulmonary Vascular Complications of Liver Disease Study Group – 28 August 2008 – Chronic obstructive pulmonary disease (COPD) may cause significant symptoms and have an impact on survival. Smoking is an important risk factor for COPD and is common in candidates for liver transplantation; however, the risk factors for and outcomes of COPD in this population are unknown.

The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantation

Ibrahim A. Hanouneh, Ariel E. Feldstein, Arthur J. McCullough, Charles Miller, Federico Aucejo, Lisa Yerian, Rocio Lopez, Nizar N. Zein – 28 August 2008 – Although hyperinsulinemia and its associated metabolic syndrome (MS) have been implicated in the progression of hepatic fibrosis in hepatitis C virus (HCV) patients, little is known about the consequences of MS after orthotopic liver transplantation (OLT). The aim of this study was to assess the association between MS and fibrosis progression in patients with recurrent HCV after OLT.

Chickenpox‐associated fulminant hepatitis that led to liver transplantation in a 63‐year‐old woman

Anne‐Marie Roque‐Afonso, Marie‐Pierre Bralet, Philippe Ichai, Delphine Desbois, Parissa Vaghefi, Denis Castaing, Didier Samuel, Elisabeth Dussaix – 28 August 2008 – A 63‐year‐old woman treated with prednisone for sinusitis developed fulminant liver failure due to a clinically unsuspected primary varicella zoster virus infection. The diagnosis of herpetic hepatitis was made from a liver biopsy, and varicella zoster virus viremia was detected by polymerase chain reaction. She was treated successfully with transplantation and perioperative administration of acyclovir.

Accuracy of an age‐adjusted formula in assessing the graft volume in living donor liver transplantation

Hiroto Kayashima, Akinobu Taketomi, Yusuke Yonemura, Hideki Ijichi, Noboru Harada, Tomoharu Yoshizumi, Yuji Soejima, Kengo Yoshimitsu, Yoshihiko Maehara – 28 August 2008 – In living donor liver transplantation, the estimated graft volume (GV) from young donors tends to be overestimated. One reason for this error may be a decrease in GV due to dehydration by University of Wisconsin (UW) solution. The aim of this study was to clarify (1) the usefulness of an age‐adjusted formula and (2) the correlation between the decrease in GV and donor age.

Long‐term outcome of mycophenolate mofetil rescue therapy for resistant acute allograft rejection in pediatric liver transplant recipients

Marion Margaret Aw, Anita Verma, Mohamed Rela, Nigel Heaton, Giorgina Mieli‐Vergani, Anil Dhawan – 28 August 2008 – Mycophenolate mofetil (MMF) has been used to rescue liver allografts with steroid‐resistant rejection (SRR). However, the long‐term outcome of these patients is not known. This study evaluates the long‐term outcome of MMF rescue therapy for SRR in pediatric liver allograft recipients. Twenty‐six children (who received 28 liver transplants), including 16 girls, were given MMF for SRR. The median age at transplant was 1.7 (range 0.4‐13.6) years.

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