| AASLD

Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas

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Marc‐Oliver Riener, Frank Stenner, Heike Liewen, Christopher Soll, Stefan Breitenstein, Bernhard Cornelius Pestalozzi, Panagiotis Samaras, Nicole Probst‐Hensch, Claus Hellerbrand, Beat Müllhaupt, Pierre‐Alain Clavien, Marcus Bahra, Peter Neuhaus, Peter Wild, Florian Fritzsche, Holger Moch, Wolfram Jochum, Glen Kristiansen – 27 April 2009 – Hepatocellular carcinomas (HCCs) and bile duct carcinomas (BDCs) have a poor prognosis. Therefore, surveillance strategies including sensitive and specific serum markers for early detection are needed.

Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide‐induced liver injury caused by ethanol in mice

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Juliane I. Beier, James P. Luyendyk, Luping Guo, Claudia von Montfort, Donald E. Staunton, Gavin E. Arteel – 27 April 2009 – The early stages of alcohol‐induced liver injury involve chronic inflammation. Whereas mechanisms by which this effect is mediated are not completely understood, it is hypothesized that enhanced sensitivity to circulating lipopolysaccharide (LPS) contributes to this process. It has recently been shown that ethanol induces activation of plasminogen activator inhibitor‐1 (PAI‐1).

Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways

Read more about Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways

Mohamed Hassan, Denis Selimovic, Hanan Ghozlan, Ola Abdel‐kader – 27 April 2009 – Chronic hepatitis C virus (HCV) infection is associated with the production of serum cytokines, including transforming growth factor (TGF)‐β2. Despite the occurrence of hepatic angiogenesis in liver conditions, the role of HCV proteins in this context is currently unknown.

NIH Development Panel Members.

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27 April 2009

Biliary obstruction as a complication of transjugular intrahepatic portosystemic shunt

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Doris Duller, Daniela Kniepeiss, Carolin Lackner, Rupert H. Portugaller, Estrella Jakoby, Silvia Schaffellner, Philipp Stiegler, Kahn Judith, Helmut Mueller, Regina Roller, Karl Heinz Tscheliessnigg, Florian Iberer – 27 April 2009

Transjugular intrahepatic portosystemic shunt to keep vein open

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Patrick P. McHugh, Gabriel J. Bietz, Hoonbae Jeon, Thomas D. Johnston, Roberto Gedaly, Dinesh Ranjan – 27 April 2009

What's in a name, AKI?

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Connie L. Davis – 27 April 2009

Rho‐kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion

Read more about Rho‐kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion

Carmen Chak‐Lui Wong, Chun‐Ming Wong, Edmund Kwok‐Kwan Tung, Kwan Man, Irene Oi‐Lin Ng – 27 April 2009 – Deregulation of Rho family small guanosine triphosphatases has been implicated in human carcinogenesis. Rho‐kinases are downstream effectors of Rho guanosine triphosphatases in the regulation of cytoskeletal reorganization and cell motility. However, their functions in human cancers remain elusive. In this study, we aimed to investigate the role of Rho‐kinases in hepatocellular carcinoma (HCC) tumor progression and invasion.