The myth of occult hepatitis C infection
Philippe Halfon, Michele Martinot‐Peignoux, Patrice Cacoub – 29 October 2009
Identification of androgen response elements in the enhancer I of hepatitis B virus: A mechanism for sex disparity in chronic hepatitis B
Sheng‐Han Wang, Shiou‐Hwei Yeh, Wei‐Hsiang Lin, Hurng‐Yi Wang, Ding‐Shinn Chen, Pei‐Jer Chen – 29 October 2009 – Hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) occurs more often in men than in women. Male HBV carriers usually have higher viral loads, which is a well‐known risk factor for HCC. Whether and how the male androgen axis regulates HBV transcription and replication is investigated here. We used HBV transgenic mice to evaluate any sex disparity of serum hepatitis B surface antigen and HBV titers as well as the castration effect on this disparity.
The β2 integrin CD11b attenuates polyinosinic:Polycytidylic acid–induced hepatitis by negatively regulating natural killer cell functions
Minggang Zhang, Yanmei Han, Chaofeng Han, Sheng Xu, Yan Bao, Zhubo Chen, Yan Gu, Dajing Xia, Xuetao Cao – 29 October 2009 – The β2 integrins play a key role in inflammation and immune responses. The β2 integrin CD11b has been shown recently to be important in the maintenance of tolerance; however, the underlying mechanisms remain to be fully understood. Natural killer (NK) cells are an important effector of innate immunity but are also a regulator of adaptive immune response.
Farnesyltransferase inhibitors reduce ras activation and ameliorate acetaminophen‐induced liver injury in mice
Banishree Saha, Dipankar Nandi – 29 October 2009 – Hepatotoxicity due to overdose of the analgesic and antipyretic acetaminophen (APAP) is a major cause of liver failure in adults. To better understand the contributions of different signaling pathways, the expression and role of Ras activation was evaluated after oral dosing of mice with APAP (400–500 mg/kg). Ras–guanosine triphosphate (GTP) is induced early and in an oxidative stress‐dependent manner.
Reply:
Neal D. Freedman, Teresa M. Curto, James E. Everhart – 29 October 2009
Comment on the PROVE1 and PROVE2 clinical trials: “I was taking a picture of rapid virological response with telaprevir, but the background is unfocused!”
Leonardo Baiocchi, Ilaria Lenci, Marco Carbone, Mario Angelico – 29 October 2009
What is the real gain after liver transplantation?
James Neuberger – 29 October 2009 – Key Points
Late surgical complications following liver transplantation
Paige M. Porrett, John Hsu, Abraham Shaked – 29 October 2009 – Key Points
Sexual dysfunction after liver transplantation
Patrizia Burra – 29 October 2009 – Key Points
Immature myeloid cells induced by a high‐fat diet contribute to liver inflammation
Zhong‐bin Deng, Yuelong Liu, Cunren Liu, Xiaoyu Xiang, Jianhua Wang, Ziqiang Cheng, Spandan V. Shah, Shuangyin Zhang, Liming Zhang, Xiaoying Zhuang, Sue Michalek, William E. Grizzle, Huang‐Ge Zhang – 29 October 2009 – Chronic inflammation plays a critical role in promoting obesity‐related disorders, such as fatty liver disease. The inflammatory cells that mediate these effects remain unknown. This study investigated the accumulation of immature myeloid cells in the liver and their role in liver inflammation.