Safety and effectiveness of ezetimibe in liver transplant recipients with hypercholesterolemia

Fawaz Almutairi, Theresa C. Peterson, Michele Molinari, Mark J. Walsh, Ian Alwayn, Kevork M. Peltekian – 27 April 2009 – Hypercholesterolemia is a common problem among transplant recipients. Despite package‐insert warnings about the potential side effects of the use of statins in patients with chronic liver disease, they are often prescribed for liver transplant recipients. Unlike statins, ezetimibe acts through inhibition of enterohepatic recirculation of lipids.

Bile acids: Trying to understand their chemistry and biology with the hope of helping patients

Alan F. Hofmann – 27 April 2009 – An informal review of the author's five decades of research on the chemistry and biology of bile acids in health and disease is presented. The review begins with a discussion of bile acid structure and its remarkable diversity in vertebrates. Methods for tagging bile acids with tritium for metabolic or transport studies are summarized. Bile acids solubilize polar lipids in mixed micelles; progress in elucidating the structure of the mixed micelle is discussed.

Association between hypothyroidism and hepatocellular carcinoma: A case‐control study in the United States

Manal M. Hassan, Ahmed Kaseb, Donghui Li, Yehuda Z. Patt, Jean‐Nicolas Vauthey, Melanie B. Thomas, Steven A. Curley, Margaret R. Spitz, Steven I. Sherman, Eddie K. Abdalla, Marta Davila, Richard D. Lozano, Deena M. Hassan, Wenyaw Chan, Thomas D. Brown, James L. Abbruzzese – 27 April 2009 – Thyroid hormones play an essential role in lipid mobilization, lipid degradation, and fatty acid oxidation.

Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE‐induced murine model of chronic liver injury

Noémi K. M. Van Hul, Jorge Abarca‐Quinones, Christine Sempoux, Yves Horsmans, Isabelle A. Leclercq – 27 April 2009 – In chronic liver injury, liver progenitor cells (LPCs) proliferate in the periportal area, migrate inside the lobule, and undergo further differentiation. This process is associated with extracellular matrix (ECM) remodeling. We analyzed LPC expansion and matrix accumulation in a choline‐deficient, ethionine‐supplemented (CDE) model of LPC proliferation. After day 3, CDE induced collagen deposits in the periportal area.

Gene expression profiling of acute cellular rejection in rat liver transplantation using DNA microarrays

Naoki Hama, Yuka Yanagisawa, Keizo Dono, Shogo Kobayashi, Shigeru Marubashi, Hiroaki Nagano, Koji Umeshita, Shinya Watanabe, Yasuo Uchiyama, Morito Monden – 27 April 2009 – Acute cellular rejection (ACR) is still a major problem in organ transplantation, and its genetic and molecular mechanisms remain poorly understood. We used DNA microarrays to investigate the gene expression profiles in ACR. We hypothesized that changes of gene expression in grafts could also be detected in peripheral blood leukocytes.

Successful liver transplantation for Budd‐Chiari syndrome in a patient with paroxysmal nocturnal hemoglobinuria treated with the anti‐complement antibody eculizumab

Andrew L. Singer, Jamye E. Locke, Zoe A. Stewart, Bonnie E. Lonze, James P. Hamilton, Jennifer R. Scudiere, Robert A. Anders, Russell P. Rother, Robert A. Brodsky, Andrew M. Cameron – 27 April 2009 – Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hemolytic anemia caused by somatic mutations in the phosphatidylinositol glycan‐complementation class A gene and the resulting absence of a key complement regulatory protein, CD59.

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