Hereditary hemochromatosis in the post‐HFE era

John K. Olynyk, Debbie Trinder, Grant A. Ramm, Robert S. Britton, Bruce R. Bacon – 16 July 2008 – Following the discovery of the HFE gene in 1996 and its linkage to the iron overload disorder hereditary hemochromatosis (HH) there have been profound developments in our understanding of the pathogenesis of the biochemical and clinical manifestations of a number of iron overload disorders.

Interface hepatitis is associated with a high incidence of late graft fibrosis in a group of tightly monitored pediatric orthotopic liver transplantation patients

Denise Herzog, Dorothée Bouron‐Dal Soglio, Jean‐Christophe Fournet, Steven Martin, Denis Marleau, Fernando Alvarez – 25 June 2008 – Chronic graft dysfunction, manifesting with elevated liver enzymes and histological features of interface hepatitis (IH), is being increasingly recognized as a long‐term problem after liver transplantation. The aim of this study was to characterize our group of post–orthotopic liver transplantation (OLT) patients with respect to clinical, laboratory, and histological signs of IH.

Platelets in liver transplantation: Friend or foe?

Ilona T. A. Pereboom, Ton Lisman, Robert J. Porte – 25 June 2008 – Apart from the well‐known role of blood platelets in hemostasis, there is emerging evidence that platelets have various nonhemostatic properties that play a critical role in inflammation, angiogenesis, tissue repair and regeneration, and ischemia/reperfusion (I/R) injury. All these processes may be involved in the (patho)physiological alterations occurring in patients undergoing liver transplantation.

Subscribe to