Liver transplantation for porphyria: Who, when, and how?

Avnish Kumar Seth, Michael N. Badminton, Darius Mirza, Scott Russell, Elwyn Elias – 30 August 2007 – Porphyrias are a heterogenous group of diseases that may result in disabling or life threatening neurovisceral symptoms and/or cutaneous photosensitivity. In acute intermittent porphyria, the clinical features, particularly neurological symptoms, may be life‐threatening and disabling. Conventional treatment with human hemin, though effective in reducing symptoms, does not reverse neuropathy when structural nerve damage has occurred and may cause intense phlebitis.

Excellent results of cardiac surgery in patients with previous liver transplantation

Farzan Filsoufi, Parwis B. Rahmanian, Javier G. Castillo, Eva Karlof, Thomas D. Schiano, David H. Adams – 30 August 2007 – Cardiovascular diseases requiring surgical therapy in patients with prior liver transplantation are rare. Little is known about the outcome of patients with liver allograft undergoing cardiac surgery. Herein we report our experience in this patient population with an emphasis on operative outcomes and mid‐term survival.

Intrahepatic portal cavernoma as an indication for liver transplantation

Cristina H. Hajdu, Takahiro Murakami, Thomas Diflo, Bachir Taouli, Jordan Laser, Lewis Teperman, Lydia M. Petrovic – 30 August 2007 – Cavernous transformation of the portal vein (portal cavernoma) consists of a periportal or/and intrahepatic venous collateral network, developed as a result of acute or long‐standing portal vein thrombosis. Better control of hemorrhagic and thrombotic complications in the patients with portal cavernoma substantially improves their life span and the clinical outcome.

Initial steroid bolus injection promotes vigorous CD8+ alloreactive responses toward early graft acceptance immediately after liver transplantation in humans

Hiroto Egawa, Shingi Uemoto, Yasutugu Takada, Kazue Ozawa, Satoshi Teramukai, Hironori Haga, Mureo Kasahara, Kouhei Ogawa, Hiroshi Sato, Masako Ono, Kenji Takai, Masanori Fukushima, Kayo Inaba, Koichi Tanaka – 30 August 2007 – We have found that steroid bolus withdrawal prior to graft reperfusion increased the incidence of acute cellular rejection (ACR). This study aims to clarify how initial steroid bolus (ISB) injection at reperfusion influences the kinetics of CD8+ alloreactive immune responses immediately after living donor liver transplantation (LDLT).

Impact of non‐congestive graft size in living donor liver transplantation: New indicator for additional vein reconstruction in right liver graft

Hideya Kamei, Yasuhiro Fujimoto, Shunji Nagai, Ryuichiro Suda, Hidekazu Yamamoto, Tetsuya Kiuchi – 30 August 2007 – Addition of the middle hepatic vein (MHV) or reconstruction of its tributaries to increase noncongestive graft volume is expected to improve graft function in right liver living donor liver transplantation (LDLT). However, the relationship between noncongestive graft volume and graft function after transplantation has not been clarified and definitive criteria for the reconstruction of MHV tributaries have yet to be established. We analyzed 29 right liver LDLT cases.

Hepatic venous pressure gradient to assess fibrosis and its progression after liver transplantation for HCV cirrhosis

Dimitrios N. Samonakis, Evangelos Cholongitas, Ulrich Thalheimer, George Kalambokis, Alberto Quaglia, Christos K. Triantos, Maria Mela, Penelope Manousou, Marco Senzolo, Amar Paul Dhillon, David Patch, Andrew Kenneth Burroughs – 30 August 2007 – Progression of fibrosis following recurrent hepatitis C virus (HCV) infection is frequent after liver transplantation (LT). Histology remains the gold standard to assess fibrosis, but the value of hepatic venous pressure gradient (HVPG) is being explored.

Subscribe to