Long‐term survival and impact of ursodeoxycholic acid treatment for recurrent primary biliary cirrhosis after liver transplantation

Phunchai Charatcharoenwitthaya, Sylvania Pimentel, Jayant A. Talwalkar, Felicity T. Enders, Keith D. Lindor, Ruud A.F. Krom, Russell H. Wiesner – 30 August 2007 – The recurrence of primary biliary cirrhosis (PBC) in the hepatic allograft may impact patient and graft survival with long‐term follow‐up. The efficacy of ursodeoxycholic acid (UDCA) for treatment of recurrent PBC after liver transplantation (LT) remains less well known.

Application of intraoperative cine‐portogram to detect spontaneous portosystemic collaterals missed by intraoperative doppler exam in adult living donor liver transplantation

Deok‐Bog Moon, Sung‐Gyu Lee, ChulSoo Ahn, Shin Hwang, Ki‐Hun Kim, TaeYong Ha, GiWon Song, JeHo Ryu, KyuBo Sung, GiYoung Ko – 30 August 2007 – Adequate portal inflow is essential to the regeneration of a partial liver graft after adult living donor liver transplantation (LDLT).

Malaria infection through multiorgan donation: An update from Spain

Monserrat Rodriguez, Santiago Tome, Luis Vizcaino, Javier Fernandez‐Castroagudin, Esteban Otero‐Anton, Esther Molina, Jorge Martinez, Gloria De la Rosa, Jose Lovo, Evaristo Varo – 30 August 2007 – During the last years, immigration has increased and, consequently, the pool of foreign donors and associated infectious diseases from exotic countries (especially from the tropics) has also increased. Only a few cases of malaria transmitted via different donation sources have been published. In the present report, a Plasmodium vivax transmitted through a multiorgan donation is reported.

Proteomic profiling of human liver biopsies: Hepatitis C virus–induced fibrosis and mitochondrial dysfunction

Deborah L. Diamond, Jon M. Jacobs, Bryan Paeper, Sean C. Proll, Marina A. Gritsenko, Robert L. Carithers, Anne M. Larson, Matthew M. Yeh, David G. Camp, Richard D. Smith, Michael G. Katze – 24 August 2007 – Liver biopsies from hepatitis C virus (HCV)‐infected patients offer the unique opportunity to study human liver biology and disease in vivo. However, the low protein yields associated with these small samples present a significant challenge for proteomic analysis.

Dispensability and dynamics of caveolin‐1 during liver regeneration and in isolated hepatic cells

Rafael Mayoral, Amalia Fernández‐Martínez, Rosa Roy, Lisardo Boscá, Paloma Martín‐Sanz – 24 August 2007 – Caveolae participate in several cellular processes such as vesicular transport, cholesterol homeostasis, regulation of signal transduction, integrin signaling, and cell growth. The expression and functional role of caveolin (Cav), the most abundant protein of caveolae, has been reported in liver and in different hepatocyte cell lines, in human cirrhotic liver, and in hepatocellular carcinomas.

Hepatitis B virus DNA is subject to extensive editing by the human deaminase APOBEC3C

Thomas F. Baumert, Christine Rösler, Michael H. Malim, Fritz von Weizsäcker – 24 August 2007 – APOBEC3G (A3G) and APOBEC3C (A3C), 2 members of the APOBEC family, are cellular cytidine deaminases displaying broad antiretroviral activity. A3G inhibits hepatitis B virus (HBV) production by interfering with HBV replication without hypermutating the majority of HBV genomes. In contrast, A3C has little effect on HBV DNA synthesis. The aim of this study was to further dissect the mechanisms by which A3G and A3C interfere with the HBV life cycle.

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