Liver transplantation using suboptimal grafts: Impact of donor harvesting technique

Francesco D'Amico, Alessandro Vitale, Enrico Gringeri, Michele Valmasoni, Amedeo Carraro, Alberto Brolese, Giacomo Zanus, Patrizia Boccagni, Davide Francesco D'Amico, Umberto Cillo – 27 September 2007 – In recent years, an increasing number of suboptimal grafts has been used to reduce the gap between the supply and demand of organs for liver transplantation (LT). In this randomized prospective study, we tested the impact of donor harvesting technique on the posttransplantation outcome of suboptimal donor livers.

Liver transplantation in patients over 60 and 65 years: An evaluation of long‐term outcomes and survival

Timothy J.S. Cross, Charalambos G. Antoniades, Paolo Muiesan, Thawab Al‐Chalabi, Varuna Aluvihare, Kosh Agarwal, Bernard C. Portmann, Mohammed Rela, Nigel D. Heaton, John G. O'Grady, Michael A. Heneghan – 27 September 2007 – With increased demand for liver transplantation (LT), outcomes of older recipients have been subjected to greater scrutiny, as previous studies have demonstrated poorer survival outcomes.

Vascular complications after orthotopic liver transplantation after neoadjuvant therapy for hilar cholangiocarcinoma

Hendrik T.J. Mantel, Charles B. Rosen, Julie K. Heimbach, Scott L. Nyberg, Michael B. Ishitani, James C. Andrews, Michael A. McKusick, Michael G. Haddock, Steven R. Alberts, Gregory J. Gores – 27 September 2007 – Liver transplantation after neoadjuvant chemoradiotherapy has emerged as an effective treatment for patients with localized, node‐negative, unresectable hilar cholangiocarcinoma (CCA) or CCA arising in the setting of primary sclerosing cholangitis (PSC).

Hepatic encephalopathy as a predictor of survival in patients with end‐stage liver disease

Charmaine A. Stewart, Michael Malinchoc, W. Ray Kim, Patrick S. Kamath – 27 September 2007 – Hepatic encephalopathy (HE) is an important component of hepatic decompensation, which reduces survival in patients with cirrhosis. The Model for End‐Stage Liver Disease (MELD) score has been used to predict survival of patients with cirrhosis. The aims of this study were to determine whether HE is a predictor of survival of patients with cirrhosis and to examine the degree to which HE may add to the survival prediction of MELD.

Absence of toll‐like receptor 4 (TLR4) signaling in the donor organ reduces ischemia and reperfusion injury in a murine liver transplantation model

Xiu‐Da Shen, Bibo Ke, Yuan Zhai, Feng Gao, Sei‐Ichiro Tsuchihashi, Charles R. Lassman, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski – 27 September 2007 – This study analyzes how toll‐like receptor 4 (TLR4) signaling in the donor organ affects the ischemia and reperfusion injury (IRI) sequel following liver transplantation. Isogenic orthotopic liver transplantations (OLTs) with rearterialization were performed in groups of wild‐type (WT) and TLR4 knockout (KO) mice after donor liver preservation in University of Wisconsin solution at 4°C for 24 hours.

Lessons learned from anatomic variants of the hepatic artery in 1,081 transplanted livers

Rafael López‐Andújar, Angel Moya, Eva Montalvá, Marina Berenguer, Manuel De Juan, Fernando San Juan, Eugenia Pareja, Juan José Vila, Francisco Orbis, Martín Prieto, José Mir – 27 September 2007 – The aim of this study is to contribute our experience to the knowledge of the anatomic variations of the hepatic arterial supply. The surgical anatomy of the extrahepatic arterial vascularization was investigated prospectively in 1,081 donor cadaveric livers, transplanted at La Fe University Hospital from January 1991 to August 2004.

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