Suppressor of cytokine signaling 3 (SOCS3) expression and hepatitis C virus–related chronic hepatitis: Insulin resistance and response to antiviral therapy

Marcello Persico, Mario Capasso, Eliana Persico, Monica Svelto, Roberta Russo, Daniela Spano, Lori Crocè, Vincenzo La Mura, Francesco Moschella, Flora Masutti, Roberto Torella, Claudio Tiribelli, Achille Iolascon – 1 August 2007 – The response to antiviral therapy is lower in hepatitis C virus (HCV) patients with genotype 1 than in those with genotype 2. Overexpression of the suppressor of cytokine signaling 3 (SOCS3) gene in liver tissue is associated with a poorer treatment outcome in patients with chronic hepatitis C viral genotype 1.

Hepatitis C treatment in “difficult‐to‐treat” psychiatric patients with pegylated interferon‐alpha and ribavirin: Response and psychiatric side effects

Martin Schaefer, Axel Hinzpeter, Ariane Mohmand, Gesa Janssen, Maurice Pich, Markus Schwaiger, Rahul Sarkar, Astrid Friebe, Andreas Heinz, Michael Kluschke, Marlene Ziemer, Juri Gutsche, Viola Weich, Juliane Halangk, Thomas Berg – 1 August 2007 – We investigated and compared the results of treating the chronic hepatitis C (HCV) infection of different groups of psychiatric‐risk patients and controls with pegylated interferon alpha (pegIFN‐α) plus ribavirin. Seventy patients were prospectively screened for psychiatric disorders.

Intraoperative stent placement in the portal vein during or after liver transplantation

Yong‐Jae Kim, Gi‐Young Ko, Hyun‐Ki Yoon, Ji‐Hoon Shin, Heung‐Kyu Ko, Kyu‐Bo Sung – 30 July 2007 – The purpose of this research was to evaluate the intermediate effectiveness of intraoperative portal vein stent placement for portal venous stenosis in liver transplantation. We attempted intraoperative portal vein stent placement in 44 portal venous anastomotic stenoses in 36 patients. All patients underwent stent placement via either the inferior or superior mesenteric vein.

Histidine‐tryptophan‐ketoglutarate solution vs. University of Wisconsin solution for liver transplantation: A systematic review

Li Feng, Na Zhao, Xun Yao, Xin Sun, Liang Du, Xiang Diao, Shengfu Li, Youping Li – 30 July 2007 – University of Wisconsin (UW) solution has been recognized as the gold standard in liver preservation, but its limitations are becoming obvious, such as risk of biliary complications and its high cost. Alternatively, the effects of histidine‐tryptophan‐ketoglutarate (HTK), such as improved biliary protection and low cost, have been observed. This systematic review is conducted to compare the efficacy and safety of these 2 solutions. Databases from 1966 to June 2006 were searched.

The impact of serum sodium concentration on mortality after liver transplantation: A cohort multicenter study

Muhammad F. Dawwas, James D. Lewsey, James M. Neuberger, Alexander E. Gimson – 30 July 2007 – Modification of the current allocation system for donor livers in the United States to incorporate recipient serum sodium concentration ([Na]) has recently been proposed. However, the impact of this parameter on posttransplantation mortality has not been previously examined in a large risk‐adjusted analysis.

An integrated MELD model including serum sodium and age improves the prediction of early mortality in patients with cirrhosis

Angelo Luca, Berhard Angermayr, Guido Bertolini, Franz Koenig, Giovanni Vizzini, Martin Ploner, Markus Peck‐Radosavljevic, Bruno Gridelli, Jaime Bosch – 30 July 2007 – The Model for End‐Stage Liver Disease (MELD) is widely used to predict the short‐term mortality in patients with cirrhosis, but potential limitations of this score have been reported. The aim of this study was to improve the score's prognostic accuracy by assessing new objective variables.

Endoscopic retrograde cholangiography in post–orthotopic liver transplant population with Roux‐en‐Y biliary reconstruction

Prabhleen Chahal, Todd H. Baron, John J. Poterucha, Charles B. Rosen – 30 July 2007 – Endoscopic retrograde cholangiography (ERC) is a well‐established modality for diagnostic and therapeutic maneuvers in pancreaticobiliary disorders. However, it is technically more challenging in patients with postsurgical anatomy like Roux‐en‐Y anastomoses. Its effectiveness in post–orthotopic liver transplantation (OLT) patients with Roux‐en‐Y biliary reconstruction has not been reported. We sought to assess the efficacy and safety of ERC in this patient population.

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