Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation
Hideyoshi Toyokawa, Atsunori Nakao, Robert J. Bailey, Michael A. Nalesnik, Takashi Kaizu, Jerome L. Lemoine, Atsushi Ikeda, Koji Tomiyama, Glenn D. Papworth, Leaf Huang, Anthony J. Demetris, Thomas E. Starzl, Noriko Murase – 27 February 2008 – The interaction of donor passenger leukocytes and host leukocytes in recipient secondary lymphoid tissues during the early posttransplantation period is crucial in directing host immune reactions toward allograft rejection or acceptance. Responsible T cell clones could be activated through the direct and indirect pathways of allorecognition.