Differential effects of calcineurin inhibitors, tacrolimus and cyclosporin a, on interferon‐induced antiviral protein in human hepatocyte cells

Kumi Hirano, Tatsuki Ichikawa, Kazuhiko Nakao, Azusa Matsumoto, Hisamitsu Miyaaki, Hidetaka Shibata, Susumu Eguchi, Mitsuhisa Takatsuki, Masanori Ikeda, Hironori Yamasaki, Nobuyuki Kato, Takashi Kanematsu, Nobuko Ishii, Katsumi Eguchi – 27 February 2008 – The premise of our study is that selective inhibition of interferon (IFN) by calcineurin inhibitors contribute to the increased severity of hepatitis C virus (HCV) posttransplantation.

Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation

Hideyoshi Toyokawa, Atsunori Nakao, Robert J. Bailey, Michael A. Nalesnik, Takashi Kaizu, Jerome L. Lemoine, Atsushi Ikeda, Koji Tomiyama, Glenn D. Papworth, Leaf Huang, Anthony J. Demetris, Thomas E. Starzl, Noriko Murase – 27 February 2008 – The interaction of donor passenger leukocytes and host leukocytes in recipient secondary lymphoid tissues during the early posttransplantation period is crucial in directing host immune reactions toward allograft rejection or acceptance. Responsible T cell clones could be activated through the direct and indirect pathways of allorecognition.

Identification of plasma membrane autoantigens in autoimmune hepatitis type 1 using a proteomics tool

Fatima Tahiri, François Le Naour, Stéphanie Huguet, René Lai‐Kuen, Didier Samuel, Catherine Johanet, Bruno Saubamea, Viviane Tricottet, Jean‐Charles Duclos‐Vallee, Eric Ballot – 27 February 2008 – Autoimmune hepatitis (AIH) is a liver disease with circulating autoantibodies predominantly directed against widely held cellular components. Because AIH is a liver‐specific disease, autoantibodies against plasma membrane antigens may be involved in its pathogenesis and have been reported; however, no definite identification has been described.

Safety and efficacy of combined use of sildenafil, bosentan, and iloprost before and after liver transplantation in severe portopulmonary hypertension

Mark J. Austin, Neil I. McDougall, Julia A. Wendon, Elizabeth Sizer, Alex S. Knisely, Mohammed Rela, Carol Wilson, Michael E. Callender, John G. O'Grady, Michael A. Heneghan – 27 February 2008 – Portopulmonary hypertension (PPHTN) represents a constrictive pulmonary vasculopathy in patients with portal hypertension. Liver transplantation (LT) may be curative and is usually restricted to patients with mild‐to‐moderate disease severity characterized by a mean pulmonary artery pressure (mPAP < 35 mm Hg).

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