Association between vascular endothelial growth factor gene polymorphisms and survival in hepatocellular carcinoma patients

Sun‐Young Kong, Joong‐Won Park, Jung An Lee, Jung Eun Park, Kyung Woo Park, Eun Kyung Hong, Chang‐Min Kim – 27 July 2007 – Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis and progression of tumor, including hepatocellular carcinoma (HCC), and elevated VEGF levels in serum and tissues have been known to be related with poor prognosis in patients with HCC. However, the effect of such polymorphisms of the VEGF gene on HCC prognosis has not been elucidated.

Selective decrease in hepatitis C virus–specific immunity among African Americans and outcome of antiviral therapy

Hugo R. Rosen, Scott J. Weston, KyungAh Im, Huiying Yang, James R. Burton, Henry Erlich, Jared Klarquist, Steven H. Belle, Virahep‐C Study Group – 27 July 2007 – Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, end‐stage liver disease, and hepatocellular carcinoma throughout the world. Considerable evidence indicates that the risk of viral persistence, natural history, and response to antiviral therapy varies among racial groups, but limited data exist on potential mechanisms to account for these differences.

Coffee drinking and hepatocellular carcinoma risk: A meta‐analysis

Francesca Bravi, Cristina Bosetti, Alessandra Tavani, Vincenzo Bagnardi, Silvano Gallus, Eva Negri, Silvia Franceschi, Carlo La Vecchia – 27 July 2007 – Several studies suggest an inverse relation between coffee drinking and risk of hepatocellular carcinoma (HCC). We conducted a meta‐analysis of published studies on HCC that included quantitative information on coffee consumption. Ten studies were retrieved (2,260 HCC cases), including 6 case–control studies from southern Europe and Japan (1551 cases) and 4 cohort studies from Japan (709 cases).

Human leukocyte antigen–associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution

Joerg Timm, Bin Li, Marcus G. Daniels, Tanmoy Bhattacharya, Laura L. Reyor, Rachel Allgaier, Thomas Kuntzen, Will Fischer, Brian E. Nolan, Jared Duncan, Julian Schulze zur Wiesch, Arthur Y. Kim, Nicole Frahm, Christian Brander, Raymond T. Chung, Georg M. Lauer, Bette T. Korber, Todd M. Allen – 27 July 2007 – CD8+ T cell responses play a key role in governing the outcome of hepatitis C virus (HCV) infection, and viral evolution enabling escape from these responses may contribute to the inability to resolve infection.

Immunoglobin G4‐hepatopathy: Association of immunoglobin G4‐bearing plasma cells in liver with autoimmune pancreatitis

Takeji Umemura, Yoh Zen, Hideaki Hamano, Shigeyuki Kawa, Yasuni Nakanuma, Kendo Kiyosawa – 27 July 2007 – Autoimmune pancreatitis (AIP) is characterized by high serum immunoglobin (Ig) G4 concentrations, lymphoplasmacytic inflammation, and a favorable response to corticosteroid treatment. Since liver dysfunction is frequently seen in AIP patients, we investigated hepatic histopathology and its clinical significance in patients with AIP.

Subscribe to