Hongjin Huang, Mitchell L. Shiffman, Scott Friedman, Ramasubbu Venkatesh, Natalie Bzowej, Olivia T. Abar, Charles M. Rowland, Joseph J. Catanese, Diane U. Leong, John J. Sninsky, Thomas J. Layden, Teresa L. Wright, Thomas White, Ramsey C. Cheung – 27 July 2007 – Clinical factors such as age, gender, alcohol use, and age‐at‐infection influence the progression to cirrhosis but cannot accurately predict the risk of developing cirrhosis in patients with chronic hepatitis C (CHC). The aim of this study was to develop a predictive signature for cirrhosis in Caucasian patients.

Dirk Nierhoff, Lauretta Levoci, Sigrid Schulte, Tobias Goeser, Leslie E. Rogler, David A. Shafritz – 27 July 2007 – Isolation of hepatic stem cells from the adult liver (AL) has not yet been achieved due to the lack of specific cell surface markers. To identify new surface markers for hepatic stem cells, we analyzed differences in the gene expression profile of embryonic day (ED) 13.5 fetal liver stem/progenitor cells (FLSPC) versus AL by complementary DNA (cDNA) microarray technology.

Ahmed M. Elsharkawy, Derek A. Mann – 27 July 2007 – Nuclear factor‐κB (NF‐κB) is a transcriptional regulator of genes involved in immunity, inflammatory response, cell fate, and function. Recent attention has focused on the pathophysiological role of NF‐κB in the diseased liver. In vivo studies using rodent models of liver disease and cell‐targeted perturbation of NF‐κB activity have revealed complex and multicellular functions in hepatic inflammation, fibrosis, and the development of hepatocellular carcinoma—a process we have termed the “inflammation‐fibrosis‐cancer axis”.

George V. Papatheodoridis, Emanuel K. Manesis, Spilios Manolakopoulos, Athanasios J. Archimandritis – 27 July 2007

Yutaka Inagaki, Reiichi Higashiyama, Tetsu Watanabe, Isao Okazaki – 27 July 2007

Richard A. Marlar – 27 July 2007

Inmaculada García‐Ruiz, Cristina Rodríguez‐Juan, Teresa Díaz‐Sanjuán, Miguel Ángel Martínez, Teresa Muñoz‐Yagüe, José A. Solís‐Herruzo – 27 July 2007 – Insulin resistance is present in almost all patients with nonalcoholic steatohepatitis (NAFLD), and mitochondrial dysfunction likely plays a critical role in the progression of fatty liver into nonalcoholic steatohepatitis. Rosiglitazone, a selective ligand of peroxisome proliferator‐activated receptor gamma (PPARγ), is an insulin sensitizer drug that has been used in a number of insulin‐resistant conditions, including NAFLD.

Etonia Y‐T. Pang, Alfa H‐C. Bai, Ka‐Fai To, Shirley M‐H. Sy, Navy L‐Y. Wong, Paul B‐S. Lai, Jeremy A. Squire, Nathalie Wong – 27 July 2007 – Metastasis is a major cause of cancer morbidity and mortality in individuals with hepatocellular carcinoma (HCC), yet little is known about the underlying molecular basis. Using genetic information derived from chromosome‐based comparative genomic hybridization, we have reported previously on regional chromosome 7q21‐q22 gains in close association with HCC progression.

Monica Miozzo, Carlo Selmi, Barbara Gentilin, Francesca R. Grati, Silvia Sirchia, Sabine Oertelt, Massimo Zuin, M. Eric Gershwin, Mauro Podda, Pietro Invernizzi – 27 July 2007 – Recent work has demonstrated enhanced X monosomy in women with primary biliary cirrhosis (PBC) as well as two other female‐predominant autoimmune diseases, systemic sclerosis and autoimmune thyroid disease.

Mitchell L. Shiffman, Jennifer Salvatore, Sarah Hubbard, Angie Price, Richard K. Sterling, R. Todd Stravitz, Velimir A. Luketic, Arun J. Sanyal – 27 July 2007 – Successful treatment of chronic HCV with peginterferon (PEGIFN) and ribavirin (RVN) is often limited by anemia. We performed the present study to determine if utilizing epoetin alpha (EPO) with or without a higher dose of RVN could enhance sustained virologic response (SVR).