Etiology‐dependent molecular mechanisms in human hepatocarcinogenesis

Christof Schlaeger, Thomas Longerich, Claudia Schiller, Peter Bewerunge, Arianeb Mehrabi, Grischa Toedt, Jörg Kleeff, Volker Ehemann, Roland Eils, Peter Lichter, Peter Schirmacher, Bernhard Radlwimmer – 26 January 2008 – Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is characterized by aggressive tumor behavior coupled with poor prognosis. Various etiologies have been linked to HCC development, most prominently chronic hepatitis B and C virus infections as well as chronic alcohol consumption.

Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes

Kosuke Matsui, Mikio Nishizawa, Takashi Ozaki, Tominori Kimura, Iwao Hashimoto, Masanori Yamada, Masaki Kaibori, Yasuo Kamiyama, Seiji Ito, Tadayoshi Okumura – 26 January 2008 – During inflammation, inducible nitric oxide synthase (iNOS) is induced to generate the important mediator nitric oxide (NO). Interleukin 1β (IL‐1β) induces iNOS messenger RNA (mRNA), iNOS protein, and NO in rat hepatocytes.

Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers

Indra Neil Guha, Julie Parkes, Paul Roderick, Dipanker Chattopadhyay, Richard Cross, Scott Harris, Philip Kaye, Alastair D. Burt, Steve D. Ryder, Guruprasad P. Aithal, Christopher P. Day, William M. Rosenberg – 26 January 2008 – The detection of fibrosis within nonalcoholic fatty liver disease (NAFLD) is important for ascertaining prognosis and the stratification of patients for emerging therapeutic intervention.

Therapeutic RNA silencing of Cys‐X3‐Cys chemokine ligand 1 gene prevents mice from adenovirus vector‐induced acute liver injury

Qingfeng Chen, Haiming Wei, Rui Sun, Jian Zhang, Zhigang Tian – 26 January 2008 – Gene therapy using adenovirus vectors may induce acute liver injury. Tissue injury induced by an adenovirus is likely associated with elevated expression of the Cys‐X3‐Cys chemokine ligand 1 (CX3CL1)/fractalkine (FKN) protein at the site of inflammation. However, the extent to which the actions of FKN contribute to liver injury remains unclear.

Adenosine monophosphate–activated protein kinase modulates the activated phenotype of hepatic stellate cells

Alessandra Caligiuri, Cristiana Bertolani, Cristina Tosti Guerra, Sara Aleffi, Sara Galastri, Marco Trappoliere, Francesco Vizzutti, Stefania Gelmini, Giacomo Laffi, Massimo Pinzani, Fabio Marra – 26 January 2008 – Adiponectin limits the development of liver fibrosis and activates adenosine monophosphate–activated protein kinase (AMPK). AMPK is a sensor of the cellular energy status, but its possible modulation of the fibrogenic properties of hepatic stellate cells (HSCs) has not been established.

CD161 expression on hepatitis C virus–specific CD8+ T cells suggests a distinct pathway of T cell differentiation

John W. Northfield, Victoria Kasprowicz, Michaela Lucas, Nadine Kersting, Bertram Bengsh, Arthur Kim, Rodney E. Phillips, Bruce D. Walker, Robert Thimme, Georg Lauer, Paul Klenerman – 26 January 2008 – Hepatitis C virus (HCV) causes chronic infection accompanied by a high risk of liver failure and hepatocellular carcinoma. CD8+ T cell responses are important in the control of viremia. However, the T cell response in chronic infection is weak both in absolute numbers and in the range of epitopes targeted.

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