Dr. H. Butt tribute
Keith D. Lindor – 26 September 2008
The hepatotoxic metabolite of acetaminophen directly activates the Keap1‐Nrf2 cell defense system
Ian M. Copple, Christopher E. Goldring, Rosalind E. Jenkins, Alvin J. L. Chia, Laura E. Randle, John D. Hayes, Neil R. Kitteringham, B. Kevin Park – 26 September 2008 – The transcription factor Nrf2 regulates the expression of numerous cytoprotective genes in mammalian cells. We have demonstrated previously that acetaminophen activates Nrf2 in mouse liver following administration of non‐hepatotoxic and hepatotoxic doses in vivo, implying that Nrf2 may have an important role in the protection against drug‐induced liver injury.
The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis
Maria J. Perugorria, M. Ujue Latasa, Alexandra Nicou, Hugo Cartagena‐Lirola, Josefa Castillo, Saioa Goñi, Umberto Vespasiani‐Gentilucci, Maria G. Zagami, Sophie Lotersztajn, Jesús Prieto, Carmen Berasain, Matias A. Avila – 26 September 2008 – The hepatic wound‐healing response to chronic noxious stimuli may lead to liver fibrosis, a condition characterized by excessive deposition of extracellular matrix. Fibrogenic cells, including hepatic stellate cells and myofibroblasts, are activated in response to a variety of cytokines, growth factors, and inflammatory mediators.
High relapse rate seen at week 72 for patients treated with R1626 combination therapy
Paul Pockros, David Nelson, Eliot Godofsky, Maribel Rodriguez‐Torres, Gregory T. Everson, Michael W. Fried, Reem Ghalib, Stephen Harrison, Lisa Nyberg, Mitchell L. Shiffman, Anna Chan, George Hill – 26 September 2008
Hepatitis E: Does it cause chronic hepatitis?
Rakesh Aggarwal – 26 September 2008
Suppressor of cytokine signaling‐1, a possible cause for regulatory T cells in hepatitis?
Yichuan Xiao, Yanyun Zhang – 26 September 2008
The specificity of liver inflammation in mouse models of primary biliary cirrhosis
David E. J. Jones, Jeremy M. Palmer, Alastair D. Burt, John A. Kirby – 26 September 2008
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Bart J. Veldt, Harry L. A. Janssen – 26 September 2008
Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models
Elizabeth P. Newberry, Susan M. Kennedy, Yan Xie, Jianyang Luo, Susan E. Stanley, Clay F. Semenkovich, Roseanne M. Crooke, Mark J. Graham, Nicholas O. Davidson – 26 September 2008 – Liver regeneration is impaired following partial hepatectomy (PH) in mice with genetic obesity and hepatic steatosis and also in wild‐type mice fed a high‐fat diet. These findings contrast with other data showing that liver regeneration is impaired in mice in which hepatic lipid accumulation is suppressed by either pharmacologic leptin administration or by disrupted glucocorticoid signaling.
Virion half‐life in chronic hepatitis B infection is strongly correlated with levels of viremia
Maura Dandri, John M. Murray, Marc Lutgehetmann, Tassilo Volz, Ansgar W. Lohse, Joerg Petersen – 26 September 2008 – Analysis of hepatitis B virus (HBV) kinetics with mathematical models may disclose new aspects of HBV infection and host response mechanisms.