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Richard A. Del Rio, Anthony B. Post, Mendel E. Singer – 27 June 2007
Sodium retention and ascites formation in a cholestatic mice model: Role of aldosterone and mineralocorticoid receptor?
Daniel Ackermann, David Mordasini, Lydie Cheval, Martine Imbert‐Teboul, Bruno Vogt, Alain Doucet – 27 June 2007 – Renal sodium retention in experimental liver cirrhosis originates from the distal nephron sensitive to aldosterone. The aims of this study were to (1) determine the exact site of sodium retention along the aldosterone‐sensitive distal nephron, and (2) to evaluate the role of aldosterone and mineralocorticoid receptor activation in this process. Liver cirrhosis was induced by bile duct ligation in either adrenal‐intact or corticosteroid‐clamped mice.
Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles
Mouna Mhamdi, Anneke Funk, Heinz Hohenberg, Hans Will, Hüseyin Sirma – 13 June 2007 – Formation of enveloped viruses involves assembly and budding at cellular membranes. In this study, we elucidated the morphogenesis of hepadnaviruses on the ultrastructural and biochemical level using duck hepatitis B virus (DHBV) as a model system. Formation of virus progeny initiates at the endoplasmic reticulum (ER) and is conserved both in vitro and in vivo.
FIB‐4: An inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest
Anaïs Vallet‐Pichard, Vincent Mallet, Bertrand Nalpas, Virginie Verkarre, Antoine Nalpas, Valérie Dhalluin‐Venier, Hélène Fontaine, Stanislas Pol – 13 June 2007 – To optimize the management of patients with chronic hepatitis C virus (HCV) infection, noninvasive tests to determine the degree of hepatic fibrosis have been developed.
Predictors of response of U.S. veterans to treatment for the hepatitis C virus
Lisa I. Backus, Derek B. Boothroyd, Barbara R. Phillips, Larry A. Mole – 13 June 2007 – The currently recommended treatment for hepatitis C virus (HCV) infection is pegylated interferon alfa (PEG‐INF) and ribavirin, which can be difficult to tolerate. More information about predicting sustained virologic response (SVR) may allow more informed treatment decisions to be made. This retrospective observational cohort study identified predictors of SVR to PEG‐INF and ribavirin in routine medical practice at 121 Department of Veterans Affairs facilities.
Hepatitis C virus protein expression causes calcium‐mediated mitochondrial bioenergetic dysfunction and nitro‐oxidative stress
Claudia Piccoli, Rosella Scrima, Giovanni Quarato, Annamaria D'Aprile, Maria Ripoli, Lucia Lecce, Domenico Boffoli, Darius Moradpour, Nazzareno Capitanio – 13 June 2007 – Hepatitis C virus (HCV) infection induces a state of oxidative stress that is more pronounced than that in many other inflammatory diseases. In this study we used well‐characterized cell lines inducibly expressing the entire HCV open‐reading frame to investigate the impact of viral protein expression on cell bioenergetics.
T cells in the liver: There is life beyond the graveyard
Patrick Bertolino, David G. Bowen, Volker Benseler – 30 May 2007
Systematic grading of surgical complications in live liver donors
Yasuhiko Sugawara, Sumihito Tamura, Masatoshi Makuuchi – 30 May 2007
De Novo nonalcoholic fatty liver disease after liver transplantation
Manal F. Abdelmalek, Anna Mae Diehl – 30 May 2007
Tissue‐type plasminogen activator deficiency exacerbates cholestatic liver injury in mice
Hongtao Wang, Yan Zhang, Robert O. Heuckeroth – 30 May 2007 – Recent studies demonstrating a role for plasminogen activator inhibitor (PAI)‐1 in cholestatic liver disease in mice suggested that tissue‐type plasminogen activator (tPA) or urokinase plasminogen activator (uPA) might be important after biliary tract obstruction. We now demonstrate that blocking tPA exacerbates liver injury after bile duct ligation (BDL).