Liver transplantation for argininosuccinic aciduria: Clinical, biochemical, and metabolic outcome

Tanya Newnham, Winita Hardikar, Katrina Allen, R. Mark Wellard, Charles Hamilton, Peter Angus, Robert Jones, Avihu Boneh – 27 December 2007 – We report successful liver transplantation in a young adult with argininosuccinic aciduria but without cirrhosis. Plasma amino acid profile normalized and brain magnetic resonance spectroscopy indicated improved metabolism after transplantation. The general well‐being of the patient and his quality of life improved.

Magnetic resonance imaging of hepatic fibrosis: Emerging clinical applications

Jayant A. Talwalkar, Meng Yin, Jeff L. Fidler, Schuyler O. Sanderson, Patrick S. Kamath, Richard L. Ehman – 27 December 2007 – Chronic liver disease and cirrhosis remains a major public health problem worldwide. While the majority of complications from chronic liver disease result from progressive hepatic fibrosis, the available diagnostic tests used in clinical practice are not sensitive or specific enough to detect occult liver injury at early or intermediate stages.

Tacrolimus and cyclosporin doses and blood levels in hepatitis C and alcoholic liver disease patients after liver transplantation

Ye H. Oo, Tracey Dudley, Peter Nightingale, Geoffrey Haydon, David Mutimer – 27 December 2007 – Hepatitis C virus (HCV)‐induced cirrhosis is the most common indication for liver transplantation (LT). However, graft reinfection is nearly universal. The choice of immunosuppression, including the calcineurin inhibitor (CNI), may have some effect on severity of recurrence and graft survival. In addition, HCV recurrence may have some impact on metabolism of immunosuppressive drugs.

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