Ivana Malovic, Karen K. Sørensen, Kjetil H. Elvevold, Geir Ivar Nedredal, Steinar Paulsen, Alexander V. Erofeev, Bård H. Smedsrød, Peter A. G. McCourt – 29 May 2007 – The purpose of this study was to identify the receptor responsible for endocytosis of denatured collagen from blood. The major site of clearance of this material (at least 0.5 g/day in humans) is a receptor on liver sinusoidal endothelial cells (LSECs). We have now identified an 180‐kDa endocytic receptor on LSECs, peptide mass fingerprinting of which revealed it to be the mannose receptor.

Teresa I. Ng, Hongmei Mo, Tami Pilot‐Matias, Yupeng He, Gennadiy Koev, Preethi Krishnan, Rubina Mondal, Ron Pithawalla, Wenping He, Tanya Dekhtyar, Jeremy Packer, Mark Schurdak, Akhteruzzaman Molla – 29 May 2007 – Hepatitis C virus (HCV) replication is highly dependent on host cell factors. Identification of these host factors not only facilitates understanding of the biology of HCV infection but also enables the discovery of novel targets for anti‐HCV therapy.

Magali Gary‐Bobo, Ghizlane Elachouri, Jean François Gallas, Philip Janiak, Pietro Marini, Christine Ravinet‐Trillou, Michèle Chabbert, Noël Cruccioli, Christian Pfersdorff, Claude Roque, Michèle Arnone, Tiziano Croci, Philippe Soubrié, Florence Oury‐Donat, Jean Pierre Maffrand, Bernard Scatton, Frederic Lacheretz, Gérard Le Fur, Jean Marc Herbert, Mohammed Bensaid – 24 May 2007 – This study investigated the effects of rimonabant (SR141716), an antagonist of the cannabinoid receptor type 1 (CB1), on obesity‐associated hepatic steatosis and related features of metabolic syndrome: inflammation

Leland J. Yee, Yong‐Ming Tang, David E. Kleiner, Dai Wang, KyungAh Im, Abdus Wahed, Xiaomei Tong, Shannon Rhodes, Xiaowen Su, R. Margaret Whelan, Robert J. Fontana, Marc G. Ghany, Brian Borg, T.

Marianne Ulcickas Yood, Charles P. Quesenberry, Dianlin Guo, Cary Caldwell, Karen Wells, Jun Shan, Lynn Sanders, Mary Lou Skovron, Uchenna Iloeje, M. Michele Manos – 24 May 2007 – Although hepatitis C virus (HCV) infection has been shown to be associated with development of non‐Hodgkin's lymphoma (NHL), few studies have investigated the association between chronic HBV infection and NHL. The purpose of this study was to compare the incidence of NHL between patients with and without chronic hepatitis B virus (HBV) infection.

Stéphane Chevaliez, Magali Bouvier‐Alias, Rozenn Brillet, Jean‐Michel Pawlotsky – 24 May 2007 – The quantification of hepatitis C virus (HCV) RNA is essential for the everyday management of chronic hepatitis C therapy. Real‐time polymerase chain reaction (PCR) techniques are potentially more sensitive than classical PCR techniques, are not prone to carryover contamination, and have a consistently wider dynamic range of quantification. Thus, they are rapidly replacing other technologies for the routine quantification of HCV RNA.

Tania Fiaschi, Francesca Buricchi, Giacomo Cozzi, Stephanie Matthias, Matteo Parri, Giovanni Raugei, Giampietro Ramponi, Paola Chiarugi – 24 May 2007 – Adiponectin/ACRP30 is an adipose tissue–derived hormone with antiatherogenic, antidiabetic, and insulin‐sensitizing properties. Although the metabolic effects of adiponectin on glucose and lipid metabolism are well known, the signaling pathways triggered by adiponectin receptors remain to be elucidated.

Jiansheng Huang, Jahangir Iqbal, Pradip K. Saha, Jun Liu, Lawrence Chan, M. Mahmood Hussain, David D. Moore, Li Wang – 24 May 2007 – The orphan receptor Small Heterodimer Partner (SHP, NROB2) regulates metabolic pathways, including hepatic bile acid, lipid, and glucose homeostasis. We reported that SHP‐deletion in leptin‐deficient OB−/− mice increases insulin sensitivity, and prevents the development of fatty liver.

Shin‐ya Morita, Aya Kobayashi, Yasukazu Takanezawa, Noriyuki Kioka, Tetsurou Handa, Hiroyuki Arai, Michinori Matsuo, Kazumitsu Ueda – 23 May 2007 – Human ABCB4 (multidrug resistance [MDR]3 P‐glycoprotein) is expressed in the canalicular membrane of the hepatocyte. ABCB4 has been shown to be required for phosphatidylcholine (PC) secretion into the bile and to translocate PC across the plasma membrane. To further investigate the function of ABCB4, we established a cell line stably expressing ABCB4 (human embryonic kidney [HEK]/ABCB4).

Wing‐Kin Syn, Peter Nightingale, Bridget Gunson, Stefan G. Hubscher, James M. Neuberger – 22 May 2007 – Unexplained chronic hepatitis (CH) in the adult liver allograft recipient is not uncommon, but its natural history and clinical significance is unknown. A retrospective study was undertaken of adult liver allograft recipients to determine the frequency and natural history of unexplained CH.