Pregnane X receptor is essential for normal progression of liver regeneration

Guoli Dai, Lin He, Pengli Bu, Yu‐Jui Yvonne Wan – 31 December 2007 – Pregnane X receptor (PXR) mediates xenobiotic and endobiotic metabolism as well as hepatocyte proliferation. To determine the role of PXR in liver regeneration, 2/3 partial hepatectomy (PH) was performed on wild‐type and PXR‐null mice. Our results showed that hepatic steatosis was markedly suppressed in mice lacking PXR 36 hours after PH, concomitant with reduction of hepatocyte proliferation at the same time point.

Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A–deficient mice

C. Bart Rountree, Shantha Senadheera, Jose M. Mato, Gay M. Crooks, Shelly C. Lu – 31 December 2007 – Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the biosynthesis of S‐adenosylmethionine. Hepatic MAT activity falls in chronic liver diseases, and mice lacking Mat1a are predisposed to liver injury and develop hepatocellular carcinoma (HCC) spontaneously by 18 months. The current work examined the hypothesis that liver cancer stem cells contribute to HCC in this model.

Biliary complications following liver transplantation in the model for end‐stage liver disease era: Effect of donor, recipient, and technical factors

Theodore H. Welling, David G. Heidt, Michael J. Englesbe, John C. Magee, Randall S. Sung, Darrell A. Campbell, Jeffrey D. Punch, Shawn J. Pelletier – 27 December 2007 – Biliary complications remain a significant problem following liver transplantation in the Model for End‐Stage Liver Disease (MELD) era. We hypothesized that donor, recipient, and technical variables may differentially affect anastomotic biliary complications in MELD era liver transplants.

Early invasive Listeria monocytogenes infection after orthotopic liver transplantation: Case report and review of the literature

Thomas Kruszyna, Mark Walsh, Kevork Peltekian, Michele Molinari – 27 December 2007 – Infection with Listeria monocytogenes is rare, with a reported annual incidence of 4.4 cases per million individuals. It is caused by a gram‐positive rod‐shaped bacterium (Listeria monocytogenes) that can be found in soil, vegetation, water, sewage, and silage and in feces of humans and animals. It is a facultative intracellular pathogen with the ability to survive and multiply in phagocytic host cells, even in adverse environmental circumstances.

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