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Frédéric Le Gal, Corinne Castelneau, Elyanne Gault, Nasser al Hawajri, Emmanuel Gordien, Patrick Marcellin, Paul Dény – 26 April 2007

Contrast‐enhanced ultrasound of histologically proven liver hemangiomas

Christoph F. Dietrich, Joachim C. Mertens, Barbara Braden, Gudrun Schuessler, Michaela Ott, Andre Ignee – 26 April 2007 – Differentiation of small and atypical hemangiomas from other hepatic masses using imaging methods can be difficult, especially in patients with underlying malignant disease. Therefore, contrast‐enhanced ultrasound was assessed in patients with histologically confirmed hemangiomas with respect to contrast‐enhancing kinetics and tumor characteristics.

The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype‐specific mechanisms

Valerio Pazienza, Sophie Clément, Paolo Pugnale, Stéphanie Conzelman, Michelangelo Foti, Alessandra Mangia, Francesco Negro – 26 April 2007 – Both molecular and clinical evidence support a link between HCV infection and insulin resistance. We examined the in vitro interaction between the HCV core protein of genotypes 3a and 1b with the insulin‐signaling pathway.

Role of S‐adenosyl‐L‐methionine in liver health and injury

José M. Mato, Shelly C. Lu – 26 April 2007 – S‐Adenosylmethionine (SAMe) has rapidly moved from being a methyl donor to a key metabolite that regulates hepatocyte growth, death, and differentiation. Biosynthesis of SAMe occurs in all mammalian cells as the first step in methionine catabolism in a reaction catalyzed by methionine adenosyltransferase (MAT). Decreased hepatic SAMe biosynthesis is a consequence of all forms of chronic liver injury.

Tim2 is expressed in mouse fetal hepatocytes and regulates their differentiation

Natsumi Watanabe, Minoru Tanaka, Kaori Suzuki, Atsushi Kumanogoh, Hitoshi Kikutani, Atsushi Miyajima – 26 April 2007 – Liver development is regulated by various extracellular molecules such as cytokines and cell surface proteins. Although several such regulators have been identified, additional molecules are likely to be involved in liver development. To identify such molecules, we employed the signal sequence trap (SST) method to screen cDNAs encoding a secreted or membrane protein from fetal liver and obtained a number of clones.

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