Noninvasive monitoring of cerebral perfusion pressure in patients with acute liver failure using transcranial doppler ultrasonography

Shushma Aggarwal, David M. Brooks, Yoogoo Kang, Peter K. Linden, John F. Patzer – 25 June 2008 – Elevated intracranial pressure (ICP) leads to loss of cerebral perfusion, cerebral herniation, and irreversible brain damage in patients with acute liver failure (ALF). Conventional techniques for monitoring ICP can be complicated by hemorrhage and infection. Transcranial doppler ultrasonography (TCD) is a noninvasive device which can continuously measure cerebral blood flow velocity, producing a velocity‐time waveform that indirectly monitors changes in cerebral hemodynamics, including ICP.

Overcoming the limitations of living donor and split liver transplantation: A proposal for adult recipients (the best of the east in the west)

Nigel Heaton, Parthi Srinivasan, Andreas Prachalias, Mohamed Rela – 25 June 2008 – A shortage of organs for liver transplantation has encouraged the development of advanced surgical strategies to increase the donor pool. We present a technical strategy that combines the established techniques of split liver transplantation and left lateral segment donation from living donors for adult recipients. This strategy could provide an additional source of organs for liver transplantation. Liver Transpl 14:932–934, 2008. © 2008 AASLD.

Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation

Lai‐Sze Grace Wong, Boon‐Hun Yong, Karl Kang Young, Lee‐Sung Lau, King‐Lik Cheng, Jeff Siu‐Fan Man, Michael G. Irwin – 25 June 2008 – The aim of the study was to compare the standard technique of cardiac output determination by pulmonary artery catheter thermodilution (PAC‐TD) with a noninvasive ultrasound Doppler monitor (USCOM Pty., Ltd., Coffs Harbour, Australia) in surgery for liver transplantation.

Cancer stem cells in the blood: Possible therapeutic implications

James D. Perkins – 25 June 2008 – Increasing evidence has revealed the importance of cancer stem cells (CSCs) in carcinogenesis. Although liver CSCs have been identified in hepatocellular carcinoma (HCC) cell lines, no data have shown the presence of these cells in human settings. The present study was designed to delineate CSCs serially from HCC cell lines, human liver cancer specimens to blood samples, using CD90 as a potential marker. The number of CD90+ cells increased with the tumorigenicity of HCC cell lines.

Ischemic preconditioning and intermittent clamping confer protection against ischemic injury in the cirrhotic mouse liver

Jae Hwi Jang, Koo‐Jeong Kang, Yuna Kang, In‐Seon Lee, Rolf Graf, Pierre‐Alain Clavien – 25 June 2008 – Surgery on cirrhotic livers is fraught with complications, and many surgeons refrain from operating on patients with cirrhosis. Surgical procedures include temporal occlusion of blood flow resulting in ischemia. The mechanisms of protective strategies to prevent ischemic injury in patients with cirrhosis are not fully understood.

Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation

Tomoharu Yoshizumi, Akinobu Taketomi, Hideaki Uchiyama, Noboru Harada, Hiroto Kayashima, Yo‐Ichi Yamashita, Yuji Soejima, Mitsuo Shimada, Yoshihiko Maehara – 25 June 2008 – No reliable model for predicting early graft function and patient survival after living donor liver transplantation (LDLT) exists. The aim of this study was to establish a new formula for predicting early graft function and prognosis using technetium‐99m galactosyl‐human serum albumin (Tc‐GSA) liver scintigraphy.

Reliability of a new ultrasonic cardiac output monitor in recipients of living donor liver transplantation

Bai‐Chuan Su, Huang‐Ping Yu, Ming‐Wen Yang, Chih‐Chung Lin, Ming‐Chang Kao, Chia‐Hung Chang, Wei‐Chen Lee – 25 June 2008 – The ultrasonic cardiac output monitor (USCOM) is a new Doppler device for noninvasive hemodynamic monitoring. The aim of this prospective nonrandomized study was to test the feasibility, perioperative reliability, and clinical applicability of using USCOM as an alternative to pulmonary artery catheterization in recipients of living donor liver transplantation. Thirteen patients scheduled to receive living donor liver transplants were initially recruited.

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