John G. O'Grady – 30 May 2007

Oren K. Fix, Nathan M. Bass, Teresa De Marco, Raphael B. Merriman – 30 May 2007 – Moderate to severe portopulmonary hypertension (PPHTN) increases the risks of orthotopic liver transplantation (OLT). Epoprostenol is an effective treatment of PPHTN, but long‐term effects on pulmonary hemodynamics or liver function in PPHTN are poorly defined. We sought to describe the long‐term effects of treatment with or without epoprostenol on pulmonary hemodynamics, liver biochemistries, and survival in patients with moderate to severe PPHTN at a single center.

Dimitrios P. Bogdanos, Christos Liaskos, Albert Pares, Gary Norman, Eirini I. Rigopoulou, Llorenç Caballeria, George N. Dalekos, Juan Rodes, Diego Vergani – 30 May 2007

Ming‐Lung Yu, Chia‐Yen Dai, Wan‐Long Chuang – 30 May 2007

David G. Koch, Lydia Christiansen, John Lazarchick, Robert Stuart, Ira R. Willner, Adrian Reuben – 30 May 2007 – Case series describing posttransplantation lymphoproliferative disorder (PTLD) after liver transplantation (LTx) have been limited in number because of the rarity of the disorder. The prevalence of Epstein‐Barr virus (EBV) infection and its detection, the clinical and histological diversity of disease, and survival have varied.

Yesim Erim, Mingo Beckmann, Sylvia Kroencke, Camino Valentin‐Gamazo, Massimo Malago, Dieter Broering, Xavier Rogiers, Andrea Frilling, Christoph E. Broelsch, Karl‐Heinz Schulz – 30 May 2007 – The ethical soundness of living donor liver transplantation (LDLT) in urgent indications is still under discussion. The aim of the survey was to investigate the psychological distress of donors in cases of hepatocellular carcinoma (HCC) or acute liver failure (ALF). In a prospective multicenter study (n = 123), health‐related quality of life (QOL), anxiety, and depression were measured.

Sven Jonas, Jens Mittler, Andreas Pascher, Guido Schumacher, Tom Theruvath, Christoph Benckert, Birgit Rudolph, Peter Neuhaus – 30 May 2007 – Living donor liver transplantation of the right lobe might offer the possibility to extend the eligibility criteria of patients with hepatocellular carcinoma (HCC) in cirrhosis without penalizing patients who are waiting for a graft from a deceased donor. From 1988 to 2005, surgical treatment of HCC was performed in 580 patients (187 transplantation, 393 resection) in a European center.

Meenakshisundaram Ananthanarayanan – 30 May 2007

Akhilesh B. Reddy, Elizabeth S. Maywood, Natasha A. Karp, Verdun M. King, Yusuke Inoue, Frank J. Gonzalez, Kathryn S. Lilley, Charalambos P. Kyriacou, Michael H. Hastings – 30 May 2007 – Circadian control of physiology is mediated by local, tissue‐based clocks, synchronized to each other and to solar time by signals from the suprachiasmatic nuclei (SCN), the master oscillator in the hypothalamus. These local clocks coordinate the transcription of key pathways to establish tissue‐specific daily metabolic programs.

Aparajita Dey, Arthur I. Cederbaum – 30 May 2007 – Cytochrome P450 2E1 (CYP2E1) activates several hepatotoxins and contributes to alcoholic liver damage. Obesity is a growing health problem in the United States. The aim of the present study was to evaluate whether acetone‐ or pyrazole‐mediated induction of CYP2E1 can potentiate liver injury in obesity. CYP2E1 protein and activity were elevated in acetone‐ or pyrazole‐treated obese and lean mice.