An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor‐α

Benjamin D. Cosgrove, Connie Cheng, Justin R. Pritchard, Donna B. Stolz, Douglas A. Lauffenburger, Linda G. Griffith – 20 June 2008 – Tumor necrosis factor‐α (TNF) is an inflammatory cytokine that induces context‐dependent proliferation, survival, and apoptosis responses in hepatocytes. TNF stimulates and enhances growth factor‐mediated hepatocyte proliferation and survival following partial hepatectomy, but also acts in concert with other inflammatory cytokines of the innate immune response during viral infection to induce apoptosis in hepatocytes.

Hepatitis C virus replication is inhibited by 22β‐methoxyolean‐12‐ene‐3β, 24(4β)‐diol (ME3738) through enhancing interferon‐β

Yoichi Hiasa, Hiroyuki Kuzuhara, Yoshio Tokumoto, Ichiro Konishi, Nobuyuki Yamashita, Bunzo Matsuura, Kojiro Michitaka, Raymond T. Chung, Morikazu Onji – 20 June 2008 – A derivative of soyasapogenol, 22β‐methoxyolean‐12‐ene‐3β, 24(4β)‐diol (ME3738), ameliorates liver injury induced by Concanavalin A in mice.

Autocrine insulin‐like growth factor‐II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis

Tanja Nussbaum, Jana Samarin, Volker Ehemann, Michaela Bissinger, Eduard Ryschich, Akmal Khamidjanov, Xiaolei Yu, Norbert Gretz, Peter Schirmacher, Kai Breuhahn – 20 June 2008 – The protumorigenic insulin‐like growth factor (IGF)‐II is highly expressed in a significant fraction of human hepatocellular carcinomas (HCC). However, a functional dissection that clarifies the contribution of IGF‐II–binding receptors in tumor progression and a respective molecular characterization of IGF‐II signaling has not been performed.

Adenosine‐dependent activation of hypoxia‐inducible factor‐1 induces late preconditioning in liver cells

Elisa Alchera, Lorenza Tacchini, Chiara Imarisio, Caterina Dal Ponte, Cristina De Ponti, Elena Gammella, Gaetano Cairo, Emanuele Albano, Rita Carini – 20 June 2008 – The cellular mechanisms by which ischemic preconditioning increases liver tolerance to ischemia/reperfusion injury are still poorly understood. This study investigated the role of the hypoxia‐inducible factor‐1 (HIF‐1) in the protection associated with the late phase of liver preconditioning.

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