The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype‐specific mechanisms
Valerio Pazienza, Sophie Clément, Paolo Pugnale, Stéphanie Conzelman, Michelangelo Foti, Alessandra Mangia, Francesco Negro – 26 April 2007 – Both molecular and clinical evidence support a link between HCV infection and insulin resistance. We examined the in vitro interaction between the HCV core protein of genotypes 3a and 1b with the insulin‐signaling pathway.