Dysregulation of glycogen synthase kinase‐3β signaling in hepatocellular carcinoma cells

Christèle Desbois‐Mouthon, Marie‐José Blivet‐Van Eggelpoë, Eléonore Beurel, Mathieu Boissan, Roland Delélo, Axelle Cadoret, Jacqueline Capeau – 7 March 2007 – It has been reported that upstream components of the insulin‐like growth factor (IGF) signaling axis could be overexpressed during hepatocarcinogenesis in humans and rodents. However, the signal transduction pathways activated downstream have been poorly studied.

Expression profiling of liver cell lines expressing entire or parts of hepatitis C virus open reading frame

Hideki Aizaki, Takashi Harada, Motoyuki Otsuka, Naohiko Seki, Mami Matsuda, Yue Wei Li, Hayato Kawakami, Yoshiharu Matsuura, Tatsuo Miyamura, Tetsuro Suzuki – 7 March 2007 – Although hepatitis C virus (HCV) is a causative agent of liver diseases, its mechanism of pathogenesis is still unclear, mainly because of the lack of adequate cell culture systems to support HCV infection and replication. In this report, we describe development and characterization of human hepatoma cell lines constitutively expressing entire (Hep394) or parts (Hep352, Hep3294) of the HCV open reading frame (ORF).

Evolution of autoimmune hepatitis to primary sclerosing cholangitis: A sequential syndrome

Ayman A. Abdo, Vincent G. Bain, Krikor Kichian, Samuel S. Lee – 7 March 2007 – Recently, the autoimmune hepatitis (AIH)/primary sclerosing cholangitis (PSC) overlap syndrome has been reported increasingly. In this syndrome, patients present with features of both AIH and PSC. It has been suggested that the 2 diseases may be sequential in their occurrence, whereby patients have features of AIH and then after a number of years develop features of PSC, but clear confirmation of evolution has not been documented in adults.

Factors associated with fulminant liver failure during an outbreak among injection drug users with acute hepatitis B

Richard S. Garfein, William A. Bower, Cherry M. Loney, Yvan J. F. Hutin, Guo‐Liang Xia, Jaspaul Jawanda, Amy V. Groom, Omana V. Nainan, James S. Murphy, Beth P. Bell – 7 March 2007 – Death related to acute hepatitis B occurs in approximately 1% of patients. We investigated an outbreak of hepatitis B virus (HBV) infections among injection drug users (IDUs) resulting in several deaths. We conducted a case‐control study of fulminant (case patients) and nonfulminant (control patients) HBV infections. We directly sequenced the entire HBV genome from fulminant and nonfulminant cases.

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