Tina L. Sumpter, Masanori Abe, Daisuke Tokita, Angus W. Thomson – 28 November 2007 – Interstitial liver dendritic cells (DCs) exhibit phenotypic diversity and functional plasticity. They play important roles in both innate and adaptive immunity. Their comparatively low inherent T cell stimulatory ability and the outcome of their interactions with CD4+ and CD8+ T cells, as well as with natural killer (NK) T cells and NK cells within the liver, may contribute to regulation of hepatic inflammatory responses and liver allograft outcome.

Mirjam B. Zeisel, George Koutsoudakis, Eva K. Schnober, Anita Haberstroh, Hubert E. Blum, François‐Loïc Cosset, Takaji Wakita, Daniel Jaeck, Michel Doffoel, Cathy Royer, Eric Soulier, Evelyne Schvoerer, Catherine Schuster, Françoise Stoll‐Keller, Ralf Bartenschlager, Thomas Pietschmann, Heidi Barth, Thomas F. Baumert – 28 November 2007 – Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide. Scavenger receptor class B type I (SR‐BI) has been shown to bind HCV envelope glycoprotein E2, participate in entry of HCV pseudotype particles, and modulate HCV infection.

José A. Solís‐Herruzo, Inmaculada García‐Ruiz – 28 November 2007

Anna Wieckowska, Arthur J. McCullough, Ariel E. Feldstein – 28 November 2007

Ian Homer Y. Cua, Jacob George – 28 November 2007

Marwan Ghabril, Justin Nguyen, David Kramer, Trina Genco, Martin Mai, Barry G. Rosser – 28 November 2007 – The liver's role as the largest organ of metabolism and the unique and often critical function of liver‐specific enzyme pathways imply a greater risk to the recipient of acquiring a donor metabolic disease with liver transplants versus other solid organ transplants. With clinical consequences rarely reported, the frequency of solid organ transplant transfer of metabolic disease is not known.

John A. Goss, Neal R. Barshes, W. Kenneth Washburn – 28 November 2007

Sukru Emre, Ronen Arnon, Emil Cohen, Raffaella A. Morotti, Dmitriy Vaysman, Benjamin L. Shneider – 28 November 2007 – Congenital absence of portal vein and extrahepatic portocaval shunt, also referred to as an Abernethy type 1, is a rare malformation of the mesenteric vasculature. A 9‐year‐old girl presented with dyspnea on exertion and orthodeoxia. A diagnosis of an Abernethy malformation type 1b and hepatopulmonary syndrome (HPS) was made, and she underwent auxiliary partial orthotopic liver transplantation (APOLT). Symptoms and signs of HPS resolved 2 months after the operation.

Harel Dahari, Alan S. Perelson – 28 November 2007

Xiong Ma, Jing Hua, Abdiaziz R. Mohamood, Abdel Rahmin A. Hamad, Rajani Ravi, Zhiping Li – 29 October 2007 – In nonalcoholic fatty liver disease, the pathogenesis of progression from simple steatosis to steatohepatitis has not been fully clarified. Many factors, including oxidative stress and hepatic immune regulation, contribute to the inflammation in steatosis. Because regulatory T cells (Tregs) are important components of immune regulation, we have now investigated their role in the pathogenesis of nonalcoholic steatohepatitis.