Hepatorenal syndrome: A proposal for kidney after liver transplantation (KALT)

Richard Ruiz, Yousri M. Barri, Linda W. Jennings, Srinath Chinnakotla, Robert M. Goldstein, Marlon F. Levy, Greg J. McKenna, Henry B. Randall, Edmund Q. Sanchez, Goran B. Klintmalm – 30 May 2007 – Hepatorenal syndrome (HRS) is a well‐recognized complication of end‐stage liver disease. Once thought to be a reversible condition with liver transplantation (LT) alone, HRS may directly contribute to the requirement for long‐term dialysis posttransplant. As a result, discussion has now focused on whether or when a kidney allograft should be considered for these patients.

Can the model for end‐stage liver disease be used to predict the prognosis in patients with Budd‐Chiari syndrome?

Sarwa Darwish Murad, W. Ray Kim, Piet C. de Groen, Patrick S. Kamath, Michael Malinchoc, Dominique‐Charles Valla, Harry L.A. Janssen – 30 May 2007 – The model for end‐stage liver disease (MELD) is a widely accepted and objective scoring system for end‐stage liver disease (ESLD) but has never been evaluated for Budd‐Chiari syndrome (BCS). We investigated whether MELD can be used to predict survival in patients with BCS. Patients with BCS (n = 237) were obtained from a large international study.

Initial clinical results of orthotopic liver transplantation for hepatic alveolar echinococcosis

Fuqiang Li, Meng Yang, Bo Li, Lunang Yan, Yong Zen, Tingfu Wen, Jichun Zao – 30 May 2007 – We analyzed the features of 7 patients who underwent orthotopic liver transplantation (OLT) from April 2001 to April 2006 for incurable hepatic alveolar echinococcosis (AE) in view of the technical features of the OLT, incidence, and type of complications, as well as patient survival.

Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis

Julia L. Newton, Mark Hudson, Phaedra Tachtatzis, Kathryn Sutcliffe, Jessie Pairman, Jennifer A. Burt, David E. J. Jones – 30 May 2007 – Patients with primary biliary cirrhosis (PBC) frequently experience significant fatigue thought to result from as‐yet‐unidentified central nervous system (CNS)‐mediated processes. Pilot studies have suggested that autonomic dysfunction is a frequent occurrence in PBC and may contribute to the pathogenesis of this fatigue.

Three‐quarters of right liver donors experienced postoperative complications

Nam‐Joon Yi, Kyung‐Suk Suh, Jai Young Cho, Hae Won Lee, Eung‐Ho Cho, Sung Hoon Yang, Yong Beom Cho, Kuhn Uk Lee – 30 May 2007 – A donor right hepatectomy (RH) is associated with a higher rate of morbidity than a left hepatectomy. Therefore, the precise morbidity should be known to improve the success of donor RH implementation. However, the rate of complication varies according to the individual definition of morbidity.

Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice

Zhongjun Dong, Jianhong Zhang, Rui Sun, Haiming Wei, Zhigang Tian – 29 May 2007 – A fraction of HBV carriers have a risk to develop liver cancer. Because liver possesses a strong regeneration capability, surgical resection of cancerous liver or transplantation with healthy liver is an alternate choice for HBV‐caused hepatocarcinoma therapy. How HBV infection affects the regeneration of hepatectomized or transplanted liver remains elusive. We report that partial hepatectomy (PHx)‐induced liver regeneration was reduced in HBV transgenic (HBV‐tg) mice, a model of human HBV infection.

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