Salvage living donor liver transplantation after prior liver resection for hepatocellular carcinoma

Shin Hwang, Sung‐Gyu Lee, Deok‐Bog Moon, Chul‐Soo Ahn, Ki‐Hun Kim, Young‐Joo Lee, Tae‐Yong Ha, Gi‐Won Song – 24 April 2007 – Salvage liver transplantation has been performed for recurrent hepatocellular carcinoma (HCC) or deterioration of liver function after primary liver resection. Because prior liver resection per se is an unfavorable condition for living donor liver transplantation (LDLT), we assessed the technical feasibility of LDLT after prior hepatectomy, and we compared the outcome of salvage LDLT with that of primary LDLT in HCC patients.

Hepatitis C recurrence and fibrosis progression are not increased after living donor liver transplantation: A single‐center study of 289 patients

Maximilian Schmeding, Ulf Peter Neumann, Gero Puhl, Marcus Bahra, Ruth Neuhaus, Peter Neuhaus – 24 April 2007 – Today, hepatitis C virus (HCV) is the leading cause for liver transplantation (LT) and viral recurrence is almost universal. It has been suggested that viral replication within the transplanted tissue might be increased in organs of reduced size such as LD grafts. In the current literature the data is controversial, with many studies lacking routine liver biopsies.

Trends in post–liver transplant survival in patients with hepatitis C between 1991 and 2001 in the united states

Paul J. Thuluvath, Karen L. Krok, Dorry L. Segev, Hwan Y. Yoo – 24 April 2007 – It has been suggested that the post–liver transplantation (LT) survival rate of patients with hepatitis C virus infection (HCV) has declined in recent years. To compare the outcome of LT in patients with HCV at various time intervals between 1991 and 2001, we used United Network for Organ Sharing data to compare the post‐LT survival of adult patients (age >18 years) with HCV with those without HCV.

Can antiplatelet prophylaxis reduce the incidence of hepatic artery thrombosis after liver transplantation?

Marco Vivarelli, Giuliano La Barba, Alessandro Cucchetti, Augusto Lauro, Massimo Del Gaudio, Matteo Ravaioli, Gian Luca Grazi, Antonio D. Pinna – 24 April 2007 – To ascertain whether postoperative antiplatelet therapy could reduce the incidence of hepatic artery thrombosis (HAT) after liver transplantation (LT), 838 consecutive adult whole‐graft LTs performed from April 1986 to August 2005 that survived beyond the first postoperative month were reviewed.

Geographic disparities in deceased donor liver transplantation within a single UNOS region

Neal R. Barshes, Natasha S. Becker, W. Kenneth Washburn, Glenn A. Halff, Thomas A. Aloia, John A. Goss – 24 April 2007 – Although the Model for End‐Stage Liver Disease (MELD) scoring system has improved the ability to measure medical urgency for transplantation, geographic disparities in the probability of being delisted as a result of complications of end‐stage liver disease or death and in the probability of orthotopic liver transplantation (OLT) remain.

Conversion to sirolimus‐based immunosuppression in maintenance liver transplantation patients

Isabelle Morard, Jérôme Dumortier, Laurent Spahr, Antoine Hadengue, Pietro Majno, Philippe Morel, Gilles Mentha, Emiliano Giostra – 24 April 2007 – Sirolimus (SRL) has been proposed to replace calcineurin inhibitors (CNI) in case of CNI‐induced toxicity. The aim of this study was to evaluate the efficacy and safety of conversion from CNI to SRL in maintenance liver transplantation (LT) patients. Between 2002 and 2006, conversion was performed in 48 patients (17 female, 31 male; mean age 57 ± 10 yr) after a median delay of 19.4 months (range 0.2–173 months) after LT.

Combined liver‐kidney transplantation in glycogen storage disease Ia: A case beyond the guidelines

Mirco Belingheri, Luciana Ghio, Ambra Sala, Francesca Menni, Laura Trespidi, Mariano Ferraresso, Luisa Berardinelli, Giorgio Rossi, Alberto Edefonti, Rossella Parini – 24 April 2007 – Glycogen storage disease type Ia (GSD Ia) is a rare metabolic disorder due to hepatic glucose‐6‐phosphatase deficiency. Although great progress has been made in managing affected patients, severe hypoglycemia, lactic acidosis, hyperlipidemia, hepatic cytolysis, and impaired kidney function are frequent.

Pediatric hepatopulmonary syndrome is seen with polysplenia/interrupted inferior vena cava and without cirrhosis

Nitika Arora Gupta, Carlos Abramowsky, Todd Pillen, Douglas Redd, Carlos Fasola, Thomas Heffron, Rene Romero – 24 April 2007 – Hepatopulmonary syndrome (HPS) is a triad of liver dysfunction, hypoxemia, and intrapulmonary vascular dilatation. We describe the prevalence and clinical features of HPS at a pediatric liver transplant center. Patients referred to Children's Healthcare of Atlanta/Emory University transplant program from February 1999 to May 2005 were reviewed. Oxygen saturation in room air was screened by percutaneous pulse oximetry.

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