Induction of cytochrome promotes liver injury in ob/ob mice

Aparajita Dey, Arthur I. Cederbaum – 30 May 2007 – Cytochrome P450 2E1 (CYP2E1) activates several hepatotoxins and contributes to alcoholic liver damage. Obesity is a growing health problem in the United States. The aim of the present study was to evaluate whether acetone‐ or pyrazole‐mediated induction of CYP2E1 can potentiate liver injury in obesity. CYP2E1 protein and activity were elevated in acetone‐ or pyrazole‐treated obese and lean mice.

A new priority policy for patients with hepatocellular carcinoma awaiting liver transplantation within the model for end‐stage liver disease system

Fabio Piscaglia, Valeria Camaggi, Matteo Ravaioli, Gian Luca Grazi, Matteo Zanello, Simona Leoni, Giorgio Ballardini, Giulia Cavrini, Antonio Daniele Pinna, Luigi Bolondi – 30 May 2007 – The best prioritization of patients with hepatocellular carcinoma (HCC) waiting for liver transplantation under the model for end‐stage liver disease (MELD) allocation system is still being debated. We analyzed the impact of a MELD adjustment for HCC, which consisted of the addition of an extra score (based on the HCC stage and waiting time) to the native MELD score.

Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells

Anne M. Wertheimer, Stephen J. Polyak, Rachel Leistikow, Hugo R. Rosen – 30 May 2007 – In the majority of cases, infection with hepatitis C virus (HCV) becomes chronic and is often associated with impaired innate and adaptive immune responses. The mechanisms underlying viral persistence and lack of protective immunity are poorly understood. Considering that dendritic cells (DCs) play critical roles in initiating and modulating immune responses, we explored the effect of HCV proteins on DC gene and protein expression, phenotype, and function.

Tonsil enlargement after liver transplantation in adults—reason enough for tonsillectomy? Two cases of tonsillar posttransplantation lymphoproliferative disease

Krzysztof Mucha, Bartosz Foroncewicz, Kazimierz Niemczyk, Bogna Ziarkiewicz‐Wróblewska, Olimpia Stanisławek‐Sut, Krzysztof Zieniewicz, Marek Krawczyk, Leszek Pączek – 30 May 2007 – Posttransplantation lymphoproliferative disease (PTLD) is a well‐known complication of solid organ and bone marrow transplantation. It is agreed that the main causes of PTLD are chronic infection with Epstein‐Barr virus (EBV); the intensity, rather then the type, of immunosuppression used; and underlying recipient disease.

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