Antiviral drug‐resistant HBV: Standardization of nomenclature and assays and recommendations for management

Anna S. Lok, Fabien Zoulim, Stephen Locarnini, Angeline Bartholomeusz, Marc G. Ghany, Jean‐Michel Pawlotsky, Yun‐Fan Liaw, Masashi Mizokami, Carla Kuiken – 27 June 2007 – Substantial advances have been made in the treatment of chronic hepatitis B in the past decade. Approved treatments for chronic hepatitis B include 2 formulations of interferon and 4 nucleos(t)ide analogues (NAs).

Telangiectatic adenoma: An entity associated with increased body mass index and inflammation

Valérie Paradis, Axelle Champault, Maxime Ronot, Lydia Deschamps, Dominique‐Charles Valla, Dominique Vidaud, Valérie Vilgrain, Jacques Belghiti, Pierre Bedossa – 27 June 2007 – What were previously called telangiectatic focal nodular hyperplasias are in fact true adenomas with telangiectatic features (TAs) without overt characterized genetic abnormalities. The aim of our study was to review a surgical series of TAs in order to describe clinical, biological, and radiological findings of these lesions and to evaluate their outcomes.

Impaired liver regeneration and increased oval cell numbers following T cell–mediated hepatitis

Ian N. Hines, Michael Kremer, Fuyumi Isayama, Ashley W. Perry, Richard J. Milton, April L. Black, Christy L. Byrd, Michael D. Wheeler – 27 June 2007 – The regeneration of liver tissue following transplantation is often complicated by inflammation and tissue damage induced by a number of factors, including ischemia and reperfusion injury and immune reactions to the donor tissue. The purpose of the current study is to characterize the effects of T cell–mediated hepatitis induced by concanavalin A (ConA) on the regenerative response in vivo.

Hepatitis C virus protein expression causes calcium‐mediated mitochondrial bioenergetic dysfunction and nitro‐oxidative stress

Claudia Piccoli, Rosella Scrima, Giovanni Quarato, Annamaria D'Aprile, Maria Ripoli, Lucia Lecce, Domenico Boffoli, Darius Moradpour, Nazzareno Capitanio – 13 June 2007 – Hepatitis C virus (HCV) infection induces a state of oxidative stress that is more pronounced than that in many other inflammatory diseases. In this study we used well‐characterized cell lines inducibly expressing the entire HCV open‐reading frame to investigate the impact of viral protein expression on cell bioenergetics.

Predictors of response of U.S. veterans to treatment for the hepatitis C virus

Lisa I. Backus, Derek B. Boothroyd, Barbara R. Phillips, Larry A. Mole – 13 June 2007 – The currently recommended treatment for hepatitis C virus (HCV) infection is pegylated interferon alfa (PEG‐INF) and ribavirin, which can be difficult to tolerate. More information about predicting sustained virologic response (SVR) may allow more informed treatment decisions to be made. This retrospective observational cohort study identified predictors of SVR to PEG‐INF and ribavirin in routine medical practice at 121 Department of Veterans Affairs facilities.

FIB‐4: An inexpensive and accurate marker of fibrosis in HCV infection. comparison with liver biopsy and fibrotest

Anaïs Vallet‐Pichard, Vincent Mallet, Bertrand Nalpas, Virginie Verkarre, Antoine Nalpas, Valérie Dhalluin‐Venier, Hélène Fontaine, Stanislas Pol – 13 June 2007 – To optimize the management of patients with chronic hepatitis C virus (HCV) infection, noninvasive tests to determine the degree of hepatic fibrosis have been developed.

Assembly and budding of a hepatitis B virus is mediated by a novel type of intracellular vesicles

Mouna Mhamdi, Anneke Funk, Heinz Hohenberg, Hans Will, Hüseyin Sirma – 13 June 2007 – Formation of enveloped viruses involves assembly and budding at cellular membranes. In this study, we elucidated the morphogenesis of hepadnaviruses on the ultrastructural and biochemical level using duck hepatitis B virus (DHBV) as a model system. Formation of virus progeny initiates at the endoplasmic reticulum (ER) and is conserved both in vitro and in vivo.

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