Rushang D. Patel, Brett D. Hollingshead, Curtis J. Omiecinski, Gary H. Perdew – 27 June 2007 – The aryl‐hydrocarbon receptor (AhR) is a basic helix‐loop‐helix/Per‐Arnt‐Sim transcription factor that can be activated by exogenous as well as endogenous ligands. AhR is traditionally associated with xenobiotic metabolism. In an attempt to identify novel target genes, C57BL/6J mice were treated with β‐naphthoflavone (BNF), a known AhR ligand, and genome‐wide expression analysis studies were performed using high‐density microarrays.

Koichi Matsuzaki, Miki Murata, Katsunori Yoshida, Go Sekimoto, Yoshiko Uemura, Noriko Sakaida, Masaki Kaibori, Yasuo Kamiyama, Mikio Nishizawa, Junichi Fujisawa, Kazuichi Okazaki, Toshihito Seki – 27 June 2007 – Many patients with chronic hepatitis caused by hepatitis C virus (HCV) infection develop liver fibrosis with high risk for hepatocellular carcinoma (HCC), but the mechanism underling this process is unclear.

Yangchao Chen, Marie C. Lin, Hong Yao, Hua Wang, Ai‐Qun Zhang, Jun Yu, Chee‐kin Hui, George K. Lau, Ming‐liang He, Joseph Sung, Hsiang‐fu Kung – 27 June 2007 – Enhancer of zeste homolog 2 (EZH2) has been shown to be overexpressed in hepatocellular (HCC). We investigated the potential role of EZH2 in HCC tumorigenesis and examined the usefulness of RNA interference (RNAi) targeting EZH2 as a form of HCC treatment. Lentivirus‐mediated RNAi was employed to knock‐down EZH2 expression in human hepatoma cells to study the function of EZH2 in tumorigenesis and evaluate the treatment efficacy.

Mirella Fraquelli, Cristina Rigamonti – 27 June 2007

Johannes Herkel, Michael P. Manns, Ansgar W. Lohse – 27 June 2007

Cara L. Mack – 27 June 2007

Jens H. Henriksen – 27 June 2007

Anna S. F. Lok, Brian J. McMahon – 27 June 2007

Ravi Jhaveri, Nancy Murray – 27 June 2007

Nathalie Ganne‐Carrié, Marianne Ziol, Victor de Ledinghen, Catherine Douvin, Patrick Marcellin, Laurent Castera, Daniel Dhumeaux, Jean‐Claude Trinchet, Michel Beaugrand – 27 June 2007