Human leukocyte antigen and adult living‐donor liver transplantation outcomes: An analysis of the organ procurement and transplantation network database

S. Simona Jakab, Victor J. Navarro, Beth W. Colombe, Constantine Daskalakis, Steven K. Herrine, Simona Rossi – 27 September 2007 – Human leukocyte antigen (HLA) compatibility has no clinically significant impact in cadaveric liver transplantation. Less is known regarding living‐donor liver transplantation (LDLT). Our prior analysis of the Organ Procurement and Transplantation Network (OPTN) database suggested a higher graft failure rate in patients who underwent LDLT from donors with close HLA match.

An assessment of interactions between hepatitis C virus and herpesvirus reactivation in liver transplant recipients using molecular surveillance

Atul Humar, Kenneth Washburn, Richard Freeman, Carlos V. Paya, Houria Mouas, Emma Alecock, Raymund R. Razonable, PV16000 Study Group – 27 September 2007 – Hepatitis C virus (HCV) has been proposed to have immunomodulatory effects in transplant recipients and may promote herpesvirus reactivation. To assess this, we compared the incidence of herpesvirus reactivation in HCV‐positive and HCV‐negative liver transplant recipients.

Liver transplantation using suboptimal grafts: Impact of donor harvesting technique

Francesco D'Amico, Alessandro Vitale, Enrico Gringeri, Michele Valmasoni, Amedeo Carraro, Alberto Brolese, Giacomo Zanus, Patrizia Boccagni, Davide Francesco D'Amico, Umberto Cillo – 27 September 2007 – In recent years, an increasing number of suboptimal grafts has been used to reduce the gap between the supply and demand of organs for liver transplantation (LT). In this randomized prospective study, we tested the impact of donor harvesting technique on the posttransplantation outcome of suboptimal donor livers.

Liver transplantation in patients over 60 and 65 years: An evaluation of long‐term outcomes and survival

Timothy J.S. Cross, Charalambos G. Antoniades, Paolo Muiesan, Thawab Al‐Chalabi, Varuna Aluvihare, Kosh Agarwal, Bernard C. Portmann, Mohammed Rela, Nigel D. Heaton, John G. O'Grady, Michael A. Heneghan – 27 September 2007 – With increased demand for liver transplantation (LT), outcomes of older recipients have been subjected to greater scrutiny, as previous studies have demonstrated poorer survival outcomes.

Vascular complications after orthotopic liver transplantation after neoadjuvant therapy for hilar cholangiocarcinoma

Hendrik T.J. Mantel, Charles B. Rosen, Julie K. Heimbach, Scott L. Nyberg, Michael B. Ishitani, James C. Andrews, Michael A. McKusick, Michael G. Haddock, Steven R. Alberts, Gregory J. Gores – 27 September 2007 – Liver transplantation after neoadjuvant chemoradiotherapy has emerged as an effective treatment for patients with localized, node‐negative, unresectable hilar cholangiocarcinoma (CCA) or CCA arising in the setting of primary sclerosing cholangitis (PSC).

Hepatic encephalopathy as a predictor of survival in patients with end‐stage liver disease

Charmaine A. Stewart, Michael Malinchoc, W. Ray Kim, Patrick S. Kamath – 27 September 2007 – Hepatic encephalopathy (HE) is an important component of hepatic decompensation, which reduces survival in patients with cirrhosis. The Model for End‐Stage Liver Disease (MELD) score has been used to predict survival of patients with cirrhosis. The aims of this study were to determine whether HE is a predictor of survival of patients with cirrhosis and to examine the degree to which HE may add to the survival prediction of MELD.

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