Impact of weight‐based ribavirin with peginterferon alfa‐2b in african americans with hepatitis C virus genotype 1

Ira M. Jacobson, Robert S. Brown, Jonathan McCone, Martin Black, Clive Albert, Michael S. Dragutsky, Firdous A. Siddiqui, Thomas Hargrave, Paul Y. Kwo, Louis Lambiase, Greg W. Galler, Victor Araya, Bradley Freilich, Joann Harvey, Louis H. Griffel, Clifford A.

Alpha‐1‐antitrypsin mutant Z protein content in individual hepatocytes correlates with cell death in a mouse model

Douglas Lindblad, Keith Blomenkamp, Jeffrey Teckman – 20 September 2007 – Alpha‐1‐antitrypsin (a1AT) deficiency is caused by homozygosity for the a1AT mutant Z gene and occurs in 1 in 2000 births. The Z mutation confers an abnormal conformation on the protein, resulting in an accumulation within the endoplasmic reticulum of hepatocytes rather than appropriate secretion. The accumulation of the mutant protein is strikingly heterogeneous within the liver.

Bone disorders in chronic liver disease

Jane Collier – 20 September 2007 – Osteomalacia rarely occurs in adult patients with chronic liver disease despite a low serum vitamin D level being reported in up to two‐thirds of patients with cirrhosis. In contrast, osteoporosis, which increases the risk of vertebral fractures, occurs in 12%‐55% of patients with cirrhosis. Although the prevalence is probably falling, as shown by a fall from 57%‐26% in patients with biliary disease requiring liver transplantation over the last 2 decades, it still accounts for significant patient morbidity.

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