Frédéric Kesteloot, Alexis Desmoulière, Isabelle Leclercq, Marc Thiry, Jorge E. Arrese, Darwin J. Prockop, Charles M. Lapière, Betty V. Nusgens, Alain Colige – 29 October 2007 – ADAMTS2 belongs to the “ADAM metallopeptidase with thrombospondin type 1 motif” (ADAMTS) family. Its primary function is to process collagen type I, II, III, and V precursors into mature molecules by excising the aminopropeptide. This process allows the correct assembly of collagen molecules into fibrils and fibers, which confers to connective tissues their architectural structure and mechanical resistance.

Ryotaro Sakamori, Tetsuo Takehara, Chihiro Ohnishi, Tomohide Tatsumi, Kazuyoshi Ohkawa, Kiyoshi Takeda, Shizuo Akira, Norio Hayashi – 29 October 2007 – Sepsis is an infection‐induced syndrome with systemic inflammatory response leading to multiorgan failure and occasionally death. During this process, signal transducer and activator of transcription 3 (STAT3) is activated in the liver, but the significance of this molecule has not been established.

Jonathan M. Maher, Matthew Z. Dieter, Lauren M. Aleksunes, Angela L. Slitt, Grace Guo, Yuji Tanaka, George L. Scheffer, Jefferson Y. Chan, Jose E. Manautou, Ying Chen, Timothy P. Dalton, Masayuki Yamamoto, Curtis D. Klaassen – 29 October 2007 – Multidrug resistance–associated proteins (Mrps) are adenosine triphosphate–dependent transporters that efflux chemicals out of cells. In the liver, Mrp2 transports bilirubin‐glucuronide, glutathione (GSH), and drug conjugates into bile, whereas Mrp3 and Mrp4 efflux these entities into blood.

Giorgio Bedogni, Lucia Miglioli, Flora Masutti, Anna Castiglione, Lory Saveria Crocè, Claudio Tiribelli, Stefano Bellentani – 29 October 2007 – Using the general population of the Dionysos Study, we followed up 144 subjects without fatty liver (FL−) and 336 with fatty liver (FL+) for a median time of 8.5 years. All subjects had suspected liver disease (SLD) defined as altered liver enzymes, high mean corpuscular volume, or low platelet count in the absence of HBV and HCV infection. Ethanol intake was assessed using a food frequency questionnaire, and FL was diagnosed using ultrasonography.

Robert M. Weinrieb, Michael R. Lucey – 29 October 2007 – Very little addiction treatment research has been done concerning smoking cessation, illicit drugs, or even alcohol abuse in liver transplant patients.

Christopher Paul Day – 29 October 2007 – Severe alcoholic steatohepatitis (ASH) is the major complication of advanced alcoholic liver disease (ALD) and has a high mortality even when treated with corticosteroids.

M. Rasool Aljabiri, Francesca Lodato, Andrew K. Burroughs – 29 October 2007

Christoph R. Werner, Ulrich M. Lauer, Christoph P. Berg, Stephan Kaiser, Burkhard Ludescher, Oliver Luz, Ruth Ladurner, Michael Gregor, Florian Graepler – 29 October 2007

Teh‐Ia Huo, Jaw‐Ching Wu, Shou‐Dong Lee – 29 October 2007

Alex Rovira, Beatriz Mínguez, F. Xavier Aymerich, Carlos Jacas, Elena Huerga, Juan Córdoba, Juli Alonso – 29 October 2007 – Focal T2‐weighted white matter lesions (WML) on brain magnetic resonance imaging (MRI), mimicking those seen in cerebrovascular small‐vessel disease described in patients with persistent hepatic encephalopathy, decreased in volume with the improvement of hepatic encephalopathy. This outcome has been interpreted as a decrease in the edema that it is proposed to be involved in the pathogenesis of hepatic encephalopathy.