Jordan J. Feld, Santosh Nanda, Ying Huang, Weiping Chen, Maggie Cam, Susan N. Pusek, Lisa M. Schweigler, Dickens Theodore, Steven L. Zacks, T. Jake Liang, Michael W. Fried – 29 October 2007 – The reasons for hepatitis C treatment failure remain unknown but may be related to different host responses to therapy. In this study, we compared hepatic gene expression in patients prior to and during peginterferon and ribavirin therapy.

Heather W. Stout‐Delgado, Yonas Getachew, Thomas E. Rogers, Bonnie C. Miller, Dwain L. Thiele – 29 October 2007 – Virally infected hepatocytes are resistant to cytotoxic lymphocyte killing by perforin‐dependent and granzyme‐dependent effector mechanisms. The present studies were designed to examine the role of serine protease inhibitor 6 (SPI‐6) in limiting granzyme B–dependent cytotoxic effector mechanisms in the liver.

Winnie Yeo, Frankie K. F. Mo – 29 October 2007

Marco Bertolotti, Chiara Gabbi, Claudia Anzivino, Lucia Carulli, Nicola Carulli – 29 October 2007

Xue‐En Liu, Liesbeth Desmyter, Chun‐Fang Gao, Wouter Laroy, Sylviane Dewaele, Valerie Vanhooren, Ling Wang, Hui Zhuang, Nico Callewaert, Claude Libert, Roland Contreras, Cuiying Chen – 29 October 2007 – We evaluated the use of blood serum N‐glycan fingerprinting as a tool for the diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis induced by hepatitis B virus (HBV). A group of 450 HBV‐infected patients with liver fibrosis or cirrhosis with or without HCC were studied.

James H. Lewis, Mary Ellen Mortensen, Steven Zweig, Mary Jean Fusco, Jeffrey R. Medoff, Rene Belder, Pravastatin in Chronic Liver Disease Study Investigators – 29 October 2007 – The hepatotoxic potential of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors in patients with underlying chronic liver disease remains controversial.

Antonio de Barros Lopes, Alexandre Araujo, Mario Reis Alvares‐da Silva – 29 October 2007

Jean‐Baptiste Nousbaum, Jean‐François Cadranel, Club Francophone pour l'Etude de l'Hypertension Portale and l'Association Nationale des Hépato‐Gastroentérologues des Hôpitaux Généraux de France – 29 October 2007

Marco Binder, Georg Kochs, Ralf Bartenschlager, Volker Lohmann – 29 October 2007 – Hepatitis C virus (HCV) has been known to replicate with extremely varying efficiencies in different host cells, even within different populations of a single human hepatoma cell line, termed Huh‐7. Several reports have implicated the retinoic‐acid inducible gene I (RIG‐I)/ interferon regulatory factor 3 (IRF‐3) pathway of the innate antiviral response with differences in host cell permissiveness to HCV.

Xiong Ma, Jing Hua, Abdiaziz R. Mohamood, Abdel Rahmin A. Hamad, Rajani Ravi, Zhiping Li – 29 October 2007 – In nonalcoholic fatty liver disease, the pathogenesis of progression from simple steatosis to steatohepatitis has not been fully clarified. Many factors, including oxidative stress and hepatic immune regulation, contribute to the inflammation in steatosis. Because regulatory T cells (Tregs) are important components of immune regulation, we have now investigated their role in the pathogenesis of nonalcoholic steatohepatitis.