Dipsticks for spontaneous bacterial peritonitis: Comments on a long‐awaited study report
Anastasios Koulaouzidis, Elmuhtady Said, Anthia Gatopoulou, John Moschos – 29 October 2007
What might be learned from acute pulmonary vasodilator testing in portopulmonary hypertension?
Karen L. Swanson – 29 October 2007
A multicenter evaluation of safety of early extubation in liver transplant recipients
M. Susan Mandell, Tamara J. Stoner, Rebecca Barnett, Abraham Shaked, Mark Bellamy, Gianni Biancofiore, Claus Niemann, Ann Walia, Youri Vater, Zung V. Tran, Igal Kam – 29 October 2007 – Small single‐institutional studies performed prior to the introduction of organ allocation using the Model for End‐Stage Liver Disease (MELD) suggest that early airway extubation of liver transplant recipients is a safe practice. We designed a multicenter study to examine adverse events associated with early extubation in patients selected for liver transplantation using MELD score.
Intrahepatic interferon‐stimulated gene responses: Can they predict treatment responses in chronic hepatitis C infection?
Nicholas A. Shackel, Geoffrey W. McCaughan – 29 October 2007
The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha‐fetoprotein regulator 2
Lorri A. Morford, Christina Davis, Lin Jin, Aneta Dobierzewska, Martha L. Peterson, Brett T. Spear – 29 October 2007 – The Glypican 3 (Gpc3) gene is expressed abundantly in the fetal liver, is inactive in the normal adult liver, and is frequently reactivated in hepatocellular carcinoma (HCC). This reactivation in HCC has led to considerable interest in Gpc3 as a diagnostic tumor marker and its possible role in tumorigenesis. Despite this interest, the basis for Gpc3 regulation is poorly understood.
Spontaneous bacterial peritonitis and reagent strips
Jose Castellote – 29 October 2007
Genomewide genetic association studies in hepatology: The end of searching for the needle in the haystack?
Claus Hellerbrand, Hermann E. Wasmuth – 29 October 2007
Liver transplantation for hepatocellular carcinoma: Role of biopsy
François Durand, Jacques Belghiti, Valérie Paradis – 29 October 2007 – Patients with compensated cirrhosis (and low Model for End‐Stage Liver Disease score) should not undergo transplantation unless they have small hepatocellular carcinoma (HCC). Therefore, presence of HCC should be definitely ascertained before deciding on transplantation in this group of patients.
ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride–induced hepatic fibrosis in mice
Frédéric Kesteloot, Alexis Desmoulière, Isabelle Leclercq, Marc Thiry, Jorge E. Arrese, Darwin J. Prockop, Charles M. Lapière, Betty V. Nusgens, Alain Colige – 29 October 2007 – ADAMTS2 belongs to the “ADAM metallopeptidase with thrombospondin type 1 motif” (ADAMTS) family. Its primary function is to process collagen type I, II, III, and V precursors into mature molecules by excising the aminopropeptide. This process allows the correct assembly of collagen molecules into fibrils and fibers, which confers to connective tissues their architectural structure and mechanical resistance.
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice
Ryotaro Sakamori, Tetsuo Takehara, Chihiro Ohnishi, Tomohide Tatsumi, Kazuyoshi Ohkawa, Kiyoshi Takeda, Shizuo Akira, Norio Hayashi – 29 October 2007 – Sepsis is an infection‐induced syndrome with systemic inflammatory response leading to multiorgan failure and occasionally death. During this process, signal transducer and activator of transcription 3 (STAT3) is activated in the liver, but the significance of this molecule has not been established.