Presentation of an acquired urea cycle disorder post liver transplantation

Marwan Ghabril, Justin Nguyen, David Kramer, Trina Genco, Martin Mai, Barry G. Rosser – 28 November 2007 – The liver's role as the largest organ of metabolism and the unique and often critical function of liver‐specific enzyme pathways imply a greater risk to the recipient of acquiring a donor metabolic disease with liver transplants versus other solid organ transplants. With clinical consequences rarely reported, the frequency of solid organ transplant transfer of metabolic disease is not known.

Resolution of hepatopulmonary syndrome after auxiliary partial orthotopic liver transplantation in abernethy malformation. A case report

Sukru Emre, Ronen Arnon, Emil Cohen, Raffaella A. Morotti, Dmitriy Vaysman, Benjamin L. Shneider – 28 November 2007 – Congenital absence of portal vein and extrahepatic portocaval shunt, also referred to as an Abernethy type 1, is a rare malformation of the mesenteric vasculature. A 9‐year‐old girl presented with dyspnea on exertion and orthodeoxia. A diagnosis of an Abernethy malformation type 1b and hepatopulmonary syndrome (HPS) was made, and she underwent auxiliary partial orthotopic liver transplantation (APOLT). Symptoms and signs of HPS resolved 2 months after the operation.

A high‐fat diet and regulatory T cells influence susceptibility to endotoxin‐induced liver injury

Xiong Ma, Jing Hua, Abdiaziz R. Mohamood, Abdel Rahmin A. Hamad, Rajani Ravi, Zhiping Li – 29 October 2007 – In nonalcoholic fatty liver disease, the pathogenesis of progression from simple steatosis to steatohepatitis has not been fully clarified. Many factors, including oxidative stress and hepatic immune regulation, contribute to the inflammation in steatosis. Because regulatory T cells (Tregs) are important components of immune regulation, we have now investigated their role in the pathogenesis of nonalcoholic steatohepatitis.

Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy

Marco Binder, Georg Kochs, Ralf Bartenschlager, Volker Lohmann – 29 October 2007 – Hepatitis C virus (HCV) has been known to replicate with extremely varying efficiencies in different host cells, even within different populations of a single human hepatoma cell line, termed Huh‐7. Several reports have implicated the retinoic‐acid inducible gene I (RIG‐I)/ interferon regulatory factor 3 (IRF‐3) pathway of the innate antiviral response with differences in host cell permissiveness to HCV.

Reply:

Jean‐Baptiste Nousbaum, Jean‐François Cadranel, Club Francophone pour l'Etude de l'Hypertension Portale and l'Association Nationale des Hépato‐Gastroentérologues des Hôpitaux Généraux de France – 29 October 2007

Subscribe to