The role of serpinb9/serine protease inhibitor 6 in preventing granzyme B–dependent hepatotoxicity

Heather W. Stout‐Delgado, Yonas Getachew, Thomas E. Rogers, Bonnie C. Miller, Dwain L. Thiele – 29 October 2007 – Virally infected hepatocytes are resistant to cytotoxic lymphocyte killing by perforin‐dependent and granzyme‐dependent effector mechanisms. The present studies were designed to examine the role of serine protease inhibitor 6 (SPI‐6) in limiting granzyme B–dependent cytotoxic effector mechanisms in the liver.

Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response

Jordan J. Feld, Santosh Nanda, Ying Huang, Weiping Chen, Maggie Cam, Susan N. Pusek, Lisa M. Schweigler, Dickens Theodore, Steven L. Zacks, T. Jake Liang, Michael W. Fried – 29 October 2007 – The reasons for hepatitis C treatment failure remain unknown but may be related to different host responses to therapy. In this study, we compared hepatic gene expression in patients prior to and during peginterferon and ribavirin therapy.

Significance of nodular regenerative hyperplasia occurring de novo following liver transplantation

Harshad Devarbhavi, Susan Abraham, Patrick S. Kamath – 29 October 2007 – Nodular regenerative hyperplasia (NRH) of the liver usually occurs in patients with rheumatological and myelolymphoproliferative disorders; the occurrence post–liver transplantation (LT) has traditionally been ascribed to the use of azathioprine. We report the clinical, biochemical, and radiological features of 14 patients who developed NRH, unrelated to azathioprine in most cases, 3 months to 11 yr after orthotopic LT.

Postoperative hyperbilirubinemia and graft outcome in living donor liver transplantation

Shigeru Marubashi, Keizo Dono, Hiroaki Nagano, Tadafumi Asaoka, Naoki Hama, Shogo Kobayashi, Atsushi Miyamoto, Yutaka Takeda, Koji Umeshita, Morito Monden – 29 October 2007 – Little information is available on the characteristics and clinical significance of serum bilirubin level early after liver transplantation. The aim of this study was to clarify the risk factors for early graft loss and to assess the significance of postoperative hyperbilirubinemia as a predictor of graft outcome in living donor liver transplantation (LDLT).

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