Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation

Takashi Ito, Yasutsugu Takada, Mikiko Ueda, Hironori Haga, Yoji Maetani, Fumitaka Oike, Kohei Ogawa, Seisuke Sakamoto, Yasuhiro Ogura, Hiroto Egawa, Koichi Tanaka, Shinji Uemoto – 28 November 2007 – In the present study, the results of living donor liver transplantation (LDLT) for 125 hepatocellular carcinoma (HCC) patients were analyzed to determine optimal criteria exceeding the Milan criteria (MC) but still with predictably good outcomes. On the basis of pretransplant imaging studies, 70 patients met the MC, and 55 patients did not.

Effect of prophylaxis on fungal infection and costs for high‐risk liver transplant recipients

Alan Reed, Jill Boylston Herndon, Nail Ersoz, Takahisa Fujikawa, Denise Schain, Paul Lipori, Alan Hemming, Qin Li, Elizabeth Shenkman, Bruce Vogel – 28 November 2007 – We sought to determine whether the prophylactic use of amphotericin B products (conventional amphotericin B and liposomal amphotericin B) reduces the incidence of fungal infections in high‐risk liver transplant recipients, and if so, whether this lowers the cost of care.

Liver retransplantation of patients with hepatitis C infection is associated with acceptable patient and graft survival

Marwan Ghabril, Rolland C. Dickson, Victor I. Machicao, Jaime Aranda‐Michel, Andrew Keaveny, Barry Rosser, Hugo Bonatti, Murli Krishna, Maria Yataco, Raj Satyanarayana, Denise Harnois, Winston Hewitt, Darin D. Willingham, Hani Grewal, Christopher B. Hughes, Justin Nguyen – 28 November 2007 – Infection with hepatitis C virus (HCV) is the leading cause of liver transplantation (LT), while liver retransplantation (RT) for HCV is controversial as a result of concerns over poor outcomes. We sought to compare patient and graft survival after RT in patients with and without HCV.

Glucocorticoid‐induced leucine zipper: A key protein in the sensitization of monocytes to lipopolysaccharide in alcoholic hepatitis

Haifa Hamdi, Amélie Bigorgne, Sylvie Naveau, Axel Balian, Laurence Bouchet‐Delbos, Anne‐Marie Cassard‐Doulcier, Marie‐Christine Maillot, Ingrid Durand‐Gasselin, Sophie Prévot, Jocelyne Delaveaucoupet, Dominique Emilie, Gabriel Perlemuter – 28 November 2007 – Glucocorticoid‐induced leucine zipper (GILZ), a recently identified protein induced by glucocorticoids (GCs), inhibits the nuclear factor κB pathway and the activation of monocytes/macrophages by lipopolysaccharides (LPS).

Hepatitis B virus infection initiates with a large surface protein–dependent binding to heparan sulfate proteoglycans

Andreas Schulze, Philippe Gripon, Stephan Urban – 28 November 2007 – Contrary to many other viruses, the initial steps of the hepatitis B virus (HBV) infection, including attachment to hepatocytes, specific receptor interactions, and membrane fusion, are unsolved. Using HepaRG cells as an in vitro cell culture system, we here report that HBV entry into hepatocytes depends on the interaction with the glycosaminoglycan (GAG) side chains of cell‐surface–associated heparan sulfate proteoglycans.

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