Should we still offer split‐liver transplantation for two adult recipients? A retrospective study of our experience

Alessandro Giacomoni, Andrea Lauterio, Matteo Donadon, Andrea De Gasperi, Luca Belli, Abdallah Slim, Bogdan Dorobantu, Iacopo Mangoni, Luciano De Carlis – 25 June 2008 – The role of split‐liver transplantation (SLT) for two adult recipients is still a matter of debate, and no agreement exists on indications, surgical techniques, and results. The aim of this study was to retrospectively analyze the outcome of our series of SLT. From May 1999 to December 2006, 16 patients underwent SLT at our unit. We used 9 full right grafts (segments 5‐8) and 7 full left grafts (segments 1‐4).

Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large‐volume center

Sung‐Gyu Lee, Shin Hwang, Deok‐Bog Moon, Chul‐Soo Ahn, Ki‐Hun Kim, Kyu‐Bo Sung, Gi‐Young Ko, Kwang‐Min Park, Tae‐Yong Ha, Gi‐Won Song – 25 June 2008 – The currently available indication criteria of living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC) have high prognostic power but insufficient discriminatory power. On the basis of single‐center results from 221 HCC patients undergoing LDLT, we modified the indication criteria for LDLT to expand recipient selection without increasing the posttransplant recurrence of HCC.

Adenosine‐dependent activation of hypoxia‐inducible factor‐1 induces late preconditioning in liver cells

Elisa Alchera, Lorenza Tacchini, Chiara Imarisio, Caterina Dal Ponte, Cristina De Ponti, Elena Gammella, Gaetano Cairo, Emanuele Albano, Rita Carini – 20 June 2008 – The cellular mechanisms by which ischemic preconditioning increases liver tolerance to ischemia/reperfusion injury are still poorly understood. This study investigated the role of the hypoxia‐inducible factor‐1 (HIF‐1) in the protection associated with the late phase of liver preconditioning.

Autocrine insulin‐like growth factor‐II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis

Tanja Nussbaum, Jana Samarin, Volker Ehemann, Michaela Bissinger, Eduard Ryschich, Akmal Khamidjanov, Xiaolei Yu, Norbert Gretz, Peter Schirmacher, Kai Breuhahn – 20 June 2008 – The protumorigenic insulin‐like growth factor (IGF)‐II is highly expressed in a significant fraction of human hepatocellular carcinomas (HCC). However, a functional dissection that clarifies the contribution of IGF‐II–binding receptors in tumor progression and a respective molecular characterization of IGF‐II signaling has not been performed.

Subscribe to